Ulcerative Colitis

CHARLOTTE, N.C. — In a Healio video exclusive, David T. Rubin, MD, FACG, reported guselkumab induced greater improvement across key outcomes compared with placebo among patients with moderate to severe ulcerative colitis.

CHARLOTTE, N.C. — A higher dose of upadacitinib decreased disease severity and induced clinical remission for a longer period among patients with active ulcerative colitis, according to a presenter at ACG Annual Scientific Meeting.

VIENNA — In a Healio video exclusive, Waqqas Afif, MD, reports results from the phase 3 UNIFI study, in which Stelara safely demonstrated sustained symptomatic and corticosteroid-free remission in adults with ulcerative colitis.

Abivax announced that the first U.S. patient has been enrolled in its global phase 3 clinical trial of its oral small-molecule inhibitor obefazimod for the treatment of moderate to severe ulcerative colitis.

In a Healio video exclusive, Simon Travis, DPhil, FRCP, consultant gastroenterologist the University of Oxford, highlighted the unmet need to treat bowel urgency among patients with ulcerative colitis.

VIENNA — In a Healio video exclusive, Maria T. Abreu, MD, reported mirikizumab induced “rapid control” of bowel movement urgency and fatigue among patients with mild to moderate ulcerative colitis.

Patients with poorly managed anxiety and pain during hospitalization had the highest risk for developing inflammatory bowel disease-related posttraumatic stress, according to research published in Inflammatory Bowel Diseases.

Two adalimumab biosimilars, adalimumab-adaz and adalimumab-fkjp, demonstrated safety and effectiveness in patients with Crohn’s disease and ulcerative colitis, according to a study in PLOS One.

In a Healio video exclusive, Freddy Caldera, DO, MS, urged providers to recommend the COVID-19 booster vaccine to all patients with inflammatory bowel disease.

Paternal and maternal use of 5-aminosalicylic acid for treatment of Crohn’s disease or ulcerative colitis before conception and during pregnancy is safe, based on offspring outcomes in a nationwide Danish cohort study.