Tumor Necrosis Factor Inhibitors

Diagnostic workups for patients with interleukin-1 mediated autoinflammatory diseases should include an audiogram and ophthalmic examination, according to data published in the Annals of the Rheumatic Diseases.

Tofacitinib shows no evidence of an increased risk for malignancies compared with TNF inhibitors when used to treat rheumatoid arthritis, according to data published in Arthritis & Rheumatology.

DESTIN, Fla. — Switching to a different drug class with a different mechanism of action can improve response in patients with difficult-to-treat rheumatoid arthritis, according to Janet Pope, MD, of Western University, in Ontario, Canada.

SAN DIEGO — Corticosteroid use should be minimized in patients with inflammatory bowel disease to reduce the risk for invasive fungal infections, according to research presented at Digestive Disease Week 2022.

In patients with rheumatoid arthritis initiating either TNF inhibitors or non-TNF inhibitor biologic therapies, severe obesity and low BMI each impeded treatment response, according to data published in Arthritis Care & Research.

Patients with rheumatoid arthritis who received tofacitinib demonstrated a greater risk for major adverse cardiovascular events and cancer than those treated with TNF inhibitors, according to data in The New England Journal of Medicine.

Among patients with inflammatory bowel disease, the effectiveness of the COVID-19 vaccine was similar when compared to controls without the disease, according to study results.

In this Healio Gastroenterology video exclusive, Miguel Regueiro, MD, FACG, discussed how anti-TNF therapy should be used as first-line therapy for treatment of inflammatory bowel disease.

In patients with rheumatoid arthritis, risk of venous thromboembolism was higher in those taking 10 mg of tofacitinib twice a day compared to 5 mg or TNF inhibitors, according to findings from the ORAL Surveillance study.

In the real-world setting, tofacitinib was not found to significantly increase risk of cardiovascular outcomes in patients with rheumatoid arthritis compared with TNF inhibitors, according to an abstract presented at ACR Convergence 2021.