Triglycerides

PHILADELPHIA — Two novel RNA interference agents, one targeting apolipoprotein C-III and one targeting angiopoietin-like protein 3, improved various lipid parameters in early studies with healthy volunteers, according to new data presented at the American Heart Association Scientific Sessions.

Tuesday, Oct. 29 is World Stroke Day, which aims to raise awareness for the treatment and prevention of stroke. In recognition, Healio presents recent highlights in stroke research.

Danish individuals with class II or III obesity are nearly three times more likely to develop acute pancreatitis during 8 years of follow-up compared with adults with normal weight, with the association mediated by hypertriglyceridemia, according to findings published in The Journal of Clinical Endocrinology & Metabolism.

CHICAGO — Findings of cardiovascular benefit with icosapent ethyl treatment from the REDUCE-IT trial have already revealed actionable clinical implications, but determining whether triglyceride reductions or eicosapentaenoic acid increases are the key mechanisms will be the focus of continuing research, according to a speaker at the Cardiometabolic Heath Congress.

Among a cohort of adults with diabetes, 20% had hypertriglyceridemia — including 19.5% of those using statins — and this condition may confer greater atherosclerotic cardiovascular disease risk, according to findings published in Diabetes Care.

BMI and insulin resistance as measured via the triglyceride glucose index share a “reciprocal” association that can influence the development of hypertension, according to findings published in Nutrition, Metabolism & Cardiovascular Diseases.

Chinese adults with triglyceride to HDL cholesterol ratios greater than 0.8533 are more likely to experience a stroke, myocardial infarction or overall cardiovascular event than those with smaller ratios, according to findings published in the Journal of Diabetes Investigation.

Volanesorsen reduced triglycerides in 77% of patients with familial chylomicronemia syndrome to less than 750 mg/dL, according to a study published in The New England Journal of Medicine.

Even without a diagnosis of nonalcoholic fatty liver disease, adults with metabolically healthy obesity are nearly twice as likely to develop diabetes as those considered to have metabolically healthy normal weight, according to data published in Diabetes Metabolism Research Reviews.