Testosterone
FDA recommends removing black box warning for CV risk from all testosterone product labels
The FDA has recommended several labeling changes to all approved testosterone replacement therapy products based on the agency’s review of several studies, according to a release.
Study: Few US adolescents receive gender-affirming medications, surgeries
Less than 0.1% of adolescents in the United States identified as transgender or gender diverse and received puberty blockers or gender-affirming hormones, according to study findings published this week in JAMA Pediatrics.
Lower SHBG concentrations tied to reduced fracture risk for men
Men with lower concentrations of sex hormone-binding globulin may be less likely to sustain a fracture than those with higher levels, according to data published in The Journal of Clinical Endocrinology & Metabolism.
No increased risk for IBD flare 1 year after gender-affirming hormone therapy
PHILADELPHIA — Although there was no overall increased risk for flare 1 year after gender-affirming hormone therapy in patients with inflammatory bowel disease, active IBD and receiving testosterone increased the likelihood of a flare.
Egg freezing unaffected by testosterone exposure for gender-diverse teens, young adults
Prior testosterone exposure did not impact oocyte cryopreservation outcomes among transgender and gender-diverse adolescents and young adults, according to a research letter published in Obstetrics & Gynecology.
Hormonal contraceptive gel for men suppresses sperm production by week 8
BOSTON — In a phase 2b trial, a hormonal contraceptive gel for use by men worked faster than expected, suppressing sperm count to effective levels by week 8 of use, making it an “attractive” product, according to a speaker at ENDO 2024.
Data show some nonbinary people prefer lower testosterone doses
BOSTON — Most nonbinary people who initiated low-dose transdermal testosterone for gender affirmation continued taking doses that were lower than current guideline recommendations at 1 year, researchers reported at ENDO 2024.
Low testosterone tied to increased risk for mortality, CVD events
Men with low testosterone concentrations had a higher risk for all-cause mortality, and those with very low testosterone also had an increased risk for CVD mortality, a study in Annals of Internal Medicine showed.
One-third of gender-affirming testosterone users report breakthrough bleeding
One-third of transgender and gender-diverse individuals on testosterone will experience at least one breakthrough bleeding episode, even after their first year of use, researchers reported in the American Journal of Obstetrics and Gynecology.
Top in endocrinology: Benefits and odds of type 2 diabetes remission
The risk for developing chronic kidney disease or cardiovascular disease is much lower among adults who achieve type 2 diabetes remission compared with those who do not, according to a post hoc analysis of the Look AHEAD trial.