Tacrolimus

Tacrolimus appears to have “synergistic” interactions with mycophenolate mofetil and cyclophosphamide for the treatment of renal involvement in systemic lupus erythematosus, according to observational data published in BMC Rheumatology.

Compared with the systemic calcineurin inhibitor standard cyclosporine, tacrolimus shows promise for numerous dermatologic conditions, whereas the literature on voclosporin is limited, according to a study.

Among pediatric patients who received a kidney-only transplantation, high tacrolimus intrapatient variability significantly correlated with de novo donor-specific antibody formation.

A number of approaches and therapies may be necessary to treat cutaneous dermatomyositis, according to a presenter at the 2021 Congress of Clinical Rheumatology-West.

This week, CHEST issues guidelines for low-dose CT screening for lung cancer; severe COVID-19 survivors experience pulmonary impairment; the FDA approves Prograf to prevent lung transplant rejection; and more.

New data showed similar clinical and endoscopic responses between tacrolimus and beclomethasone suppositories in patients with ulcerative proctitis refractory to 5-aminosalicylic acid, according to a study published in Clinical Gastroenterology and Hepatology.

A 4-year-old boy presents with a bumpy rash on the right side of his face for the past 5 months. The rash is neither pruritic nor painful. Before onset of the rash, he had a cavity treated. He is in day care with another child who was seen by a dermatologist for bumps on the skin that were treated with a cold liquid. Hydrocortisone 1% cream was tried for 2 weeks without clearance of the lesions.

The exacerbation or development of head and neck dermatitis in patients treated for atopic dermatitis with dupilumab may be caused by a dysregulation in the balance of the T helper cell signaling pathway, according to a research letter in JAMA Dermatology.