Systemic Sclerosis Disease
CAR T-cell therapies show promise, immune reset in multiple diseases at EULAR 2025
Patients with systemic lupus erythematosus who received autologous chimeric antigen receptor T-cell therapy enjoyed potent B-cell depletion and recovery, as well as improved disease activity, said a presenter at the EULAR 2025 Congress.
‘Compelling evidence’: Mycophenolate mofetil best immunosuppressive for systemic sclerosis
A comparison of immunosuppressive therapies for the treatment of diffuse cutaneous systemic sclerosis found “robust” support for mycophenolate mofetil as the first-line standard of care, according to data published in ACR Open Rheumatology.
Yankees legend Bernie Williams pays tribute to ‘superhero’ dad with ILD initiative
Former New York Yankees center fielder Bernie Williams is sharing resources for patients with interstitial lung disease as a tribute to his late father, who lost his battle with idiopathic pulmonary fibrosis in 2001.
CAR T cells one year later: What have we learned?
Nearly 1 year ago, I wrote my first editorial about the emergence and excitement surrounding the early experience with CAR T cells — CAR T Cells in Autoimmunity: A Potential Therapy About to Explode.
US Supreme Court decision on mifepristone ‘not a victory, but a punt’
On June 13, the U.S. Supreme Court rejected a lawsuit that challenged the FDA’s approach to regulating the abortion pill mifepristone.
Patient with lupus treated with KYV-101 CAR T-cell therapy relapses after 5 months
A patient with lupus nephritis treated with KYV-101, a chimeric antigen receptor T-cell immunotherapy, saw their disease return 5 months after initially showing a response to the treatment, according to the manufacturer.
‘Subclinical’ left ventricular abnormalities portend lower survival, breathlessness in SSc
Patients with systemic sclerosis who demonstrate left ventricular abnormalities, either overt or “subclinical,” have poorer survival and increased shortness of breath, according to data published in Seminars in Arthritis and Rheumatism.
A rare day for rare diseases: Latest data and findings for Rare Disease Day
It’s not too often one sees Feb. 29 on the calendar, which makes it a perfect time for Rare Disease Day, dedicated to recognizing conditions that, in the words of the European Commission on Public Health, require “special combined efforts.”
CAR T-cell therapy brings sustained, drug-free remission in three autoimmune diseases
Single injections of CD19 chimeric antigen receptor T-cell therapy brought long-lasting remission to 15 patients with three different autoimmune diseases, according to data published in The New England Journal of Medicine.
Higher gamma-glutamyl transferase levels predict greater systemic sclerosis risk
Patients with higher levels of gamma-glutamyl transferase, and particularly men, demonstrate a significantly higher risk for systemic sclerosis, according to data published in Nature Scientific Reports.