Systemic Inflammation

In a large cohort of patients with autoimmune diseases, treatment with biologic disease-modifying antirheumatic drugs was associated with reduced incidence of Parkinson’s disease, data show.

Patients with rheumatoid arthritis who demonstrate consistent long-term elevation of inflammatory markers have an increased risk for interstitial lung disease, according to data published in Arthritis Research & Therapy.

Skin inflammation, such as psoriasis, was associated with systemic inflammation, whereas both psoriasis severity and systemic inflammation were linked with cardiovascular disease, according to a study.

Air pollution exposure may contribute to both CV and cancer risk by interacting with various common risk factors such as inflammation, oxidative stress and epigenetic modifications, according to a state-of-the-art review.

In a review of nearly 500 observational studies, researchers determined that certain environmental stressors are associated with heart disease and are getting worse due to climate change.

Infection-specific processes, rather than general systemic inflammation, may play a role in the development of dementia among those with hospital-diagnosed infections, according to research from JAMA Network Open.

In patients with HF, mesenchymal precursor cell therapy reduced risk for MI and stroke, especially in those with systemic inflammation, but did not meet the primary endpoint of improvement in recurrent nonfatal decompensated HF events.

Systemic inflammation appeared to have symptom-specific rather than generalized effects on depression, according to results of a random-effects pooled analysis published in American Journal of Psychiatry.

Although the seroprevalence of SARS-CoV-2 in patients with immune-mediated inflammatory diseases is comparable to the general population, increased systemic inflammation among these patients is linked to symptomatic COVID-19, according to researchers.

Inhibition of the interleukin-6 mediated immune response with tolicizumab (Actemra, Genentech) vs. placebo in out-of-hospital cardiac arrest.