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Steatohepatitis

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June 08, 2024
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‘Unprecedented level of fibrosis improvement’ through 96 weeks with efruxifermin for MASH

‘Unprecedented level of fibrosis improvement’ through 96 weeks with efruxifermin for MASH

Treatment with efruxifermin resulted in significant improvement in fibrosis at week 24 in patients with metabolic dysfunction-associated steatohepatitis, which was “sustained and expanded through week 96,” according to late-breaking data.

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June 08, 2024
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Survodutide improves MASH without worsening of fibrosis in more than 64% at 48 weeks

Survodutide improves MASH without worsening of fibrosis in more than 64% at 48 weeks

Survodutide was superior to placebo and significantly improved markers of metabolic dysfunction-associated steatohepatitis without worsening of fibrosis, according to data presented at EASL Congress.

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June 07, 2024
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Denifanstat achieves ‘statistically significant’ improvements in liver histology in MASH

Denifanstat achieves ‘statistically significant’ improvements in liver histology in MASH

Denifanstat, a fatty acid synthase inhibitor, outperformed placebo in metabolic dysfunction-associated steatohepatitis resolution without worsening of fibrosis and fibrosis improvement, according to data presented at EASL Congress.

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May 28, 2024
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Noninvasive tests identify candidates for Rezdiffra, predict response in patients with MASH

Noninvasive tests identify candidates for Rezdiffra, predict response in patients with MASH

WASHINGTON — Researchers have determined that several noninvasive tests could help identify candidates for treatment with Rezdiffra, as well as predict response, in metabolic dysfunction-associated steatohepatitis.

CME
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The Emerging Role of Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis

The Emerging Role of Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis
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News
February 19, 2024
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VIDEO: GIs will need to become ‘better at hepatology’ ahead of looming workforce shortage

VIDEO: GIs will need to become ‘better at hepatology’ ahead of looming workforce shortage

In a Healio video exclusive, Edward V. Loftus Jr., MD, urged gastroenterologists to familiarize themselves with a “four-pronged approach to liver disease” ahead of the critical shortage of U.S. hepatologists expected by 2033.

News
December 18, 2023
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VIDEO: NAFLD upgrade to MASLD offers ‘less stigmatizing’ positive diagnosis for patients

VIDEO: NAFLD upgrade to MASLD offers ‘less stigmatizing’ positive diagnosis for patients

In a Healio video exclusive, Edward V. Loftus Jr., MD, highlighted how rebranding nonalcoholic fatty liver disease as metabolic dysfunction-associated steatotic liver disease offers a “positive diagnosis” without the associated stigma.

News
November 30, 2023
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Pegozafermin improves stage 4 fibrosis, noninvasive markers in MASH patients

Pegozafermin improves stage 4 fibrosis, noninvasive markers in MASH patients

BOSTON — Pegozafermin improved fibrosis and other key noninvasive tests at 24 weeks in patients with metabolic dysfunction-associated steatohepatitis-related cirrhosis, according to data presented at The Liver Meeting.

News
November 14, 2023
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‘Significant differences’ reported by race, ethnicity in transplant rates for MASH-HCC

‘Significant differences’ reported by race, ethnicity in transplant rates for MASH-HCC

BOSTON — Hispanic and Asian patients with metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma were less likely to undergo liver transplantation compared with other races and ethnicities, data showed.

News
October 24, 2023
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‘Often overlooked’: Insulin resistance tops risk predictors for MASLD in lean patients

‘Often overlooked’: Insulin resistance tops risk predictors for MASLD in lean patients

VANCOUVER, British Columbia — Insulin resistance, HbA1c and waist circumference represent independent risk factors for metabolic dysfunction-associated steatotic liver disease among lean patients, according to data presented here.

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