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Statin Therapy

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August 02, 2019
2 min read
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Statin discontinuation raises CV event risk by one-third in elderly

In patients aged 75 years of age or older taking statins for primary CVD prevention, discontinuing statin therapy was associated with a 33% increased risk for hospital admission for a CV event, researchers reported.

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November 21, 2018
15 min read
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New advances in preventive cardiology: A critical appraisal of 2018 cholesterol guidelines

New advances in preventive cardiology: A critical appraisal of 2018 cholesterol guidelines

The American Heart Association and the American College of Cardiology, in collaboration with multiple other societies, recently published two highly significant documents in the field of preventive cardiology.

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Triglycerides

Triglycerides are a form of lipid ester that contain glycerol and three fatty acids. There are many types of triglycerides, and they play an important role in metabolism.

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Coronary Artery Calcium (CAC) Score Topic Review

The coronary artery calcium score enhances clinical risk stratification for patients at risk for atherosclerotic coronary disease.

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March 08, 2018
5 min read
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Lipid-lowering therapy for primary prevention of CV events: Navigating the guidelines

Lipid-lowering therapy for primary prevention of CV events: Navigating the guidelines

A relative paucity of evidence guiding the use of statin therapy in the primary prevention of atherosclerotic CVD events has led to disparate treatment strategies recommended by various medical associations.

News
November 15, 2017
4 min read
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Statins are Antibiotics…is THAT the Pleiotropic Effect?

Statins have pleiotropic effects, ie the ability to reduce heart disease risk and CV death via an unknown mechanism, certainly beyond the LDL cholesterol lowering that they can achieve.

News
May 08, 2017
2 min read
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Statins: Not the Cure for Heart Disease

Right now, 40 million Americans take statins to lower cholesterol in an attempt to prevent complications of atherosclerosis such as heart disease and stroke.

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Statin Topic Review

HMG-CoA reductase inhibitors, commonly referred to as statins, are the cornerstone of pharmacologic reduction of elevated low-density lipoprotein cholesterol.

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Low Density Lipoprotein (LDL)

Low density lipoprotein (LDL) is one of several lipoprotein particles that transport cholesterol (a lipophilic molecule) through the aqueous environment of the blood. Other cholesterol carriers include high-density lipoprotein (HDL), very low density lipoprotein (VLDL) and chylomicrons. [Huff 2020;1b; Grundy 2018;7a]

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Fibric Acid Derivatives (Fibrates)

The drugs fenofibrate and gemfibrozil are considered fibric acid derivatives. They can reduce serum triglycerides by as much as 50% in some studies.

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