Statin Therapy

Lipid and lipoprotein levels have declined since the 2013 American College of Cardiology/American Heart Association cholesterol guidelines were published, according to a study published in the Journal of the American College of Cardiology.

Study results showed that while treatment with Ocaliva for nonalcoholic steatohepatitis led to an increase in LDL cholesterol at 12 weeks, levels reverted to baseline 24 weeks after discontinuation.

Two different studies regarding statins — one that indicated their use raised the risk for new-onset diabetes and a second that concluded high-dose statin therapy may heighten fracture risk — were the top stories in endocrinology last week.

Eicosapentaenoic acid, or EPA, combined with statin therapy significantly reduced the incidence of major adverse CV events, according to a meta-analysis published in The American Journal of Cardiology.

The use of statins for as little as 91 days is associated with an increased risk for skin infections via diabetogenic and nondiabetogenic mechanisms, according to findings published in the British Journal of Pharmacology.

Individuals prescribed high-dose statin therapy to manage cardiovascular risk are more likely to receive a diagnosis of osteoporosis compared with those prescribed a low-dose statin or no therapy, according to findings from a database analysis published in Annals of Rheumatic Diseases.

Patients with familial hypercholesterolemia who initiated statin therapy during childhood had a slower progression of carotid intima-media thickness and a reduced risk for CVD in adulthood, according to a study with 20-year follow-up data published in The New England Journal of Medicine.

CHICAGO —Intermittent statin dosing is a treatment option that may have tremendous potential for addressing patients with statin intolerance who are trying to reduce LDL, according to a speaker at the Cardiometabolic Health Congress.

CHICAGO — The 2018 Guideline on the Management of Blood Cholesterol, published by the American College of Cardiology and the American Heart Association in collaboration with other societies, offered a number of pointers for clinicians to diagnose, treat and manage patients with elevated cholesterol.

Statin therapy correlated with a reduced risk for hepatocellular carcinoma in patients with chronic hepatitis B, according to results published in Hepatology.