Statin Therapy
Adherence to stroke prevention guidelines improving, but still suboptimal in diabetes
More adults with type 2 diabetes achieved guideline-recommended strategies for stroke prevention in 2018 compared with 2001, but further improvements are needed, according to study findings published in Diabetes Care.
USPSTF statin recommendations for primary prevention mostly unchanged since 2016
The U.S. Preventive Services Task Force’s new recommendation statement on the use of statin therapy for primary prevention in adults aged 40 to 75 years with no history of CVD is similar to its 2016 recommendations.
No dementia, cognitive risk with PCSK9 inhibition; statin findings mixed
Data from a genetics-based study show PCSK9 inhibition does not affect cognition function or dementia risk; however, statin use may be associated with some impaired cognitive performance that is outweighed by any CV benefits.
Elevated HDL may improve SARS-CoV-2 infection resistance
LOUISVILLE, Ky. — Changes in HDL level may be linked with SARS-CoV-2 infection risk and subsequent outcomes in COVID-19, a speaker reported.
Pre-PCI evolocumab did not prevent microvascular dysfunction when added to statin therapy
Pretreatment evolocumab did not lower risk for periprocedural microvascular dysfunction in patients undergoing elective PCI for stable CAD who were already on statin therapy for high LDL, researchers reported.
Statin plus ezetimibe combination ‘alternative strategy’ to doubled statin dose in ASCVD
Among adults with atherosclerotic CVD at very high risk, moderate-intensity statin plus ezetimibe combination therapy was noninferior to high-intensity statin monotherapy for major CV outcomes at 3 years, including CV death, data show.
Statin use for CVD may lower risk for COVID-19 hospitalizations, deaths
Statin use for primary prevention of CVD was associated with lower risk for COVID-19 hospitalizations and in-hospital deaths, according to findings from a cohort study published in the Journal of the American Heart Association.
Genetic HMG-CoA reductase inhibition may raise cataract risk
Genetic inhibition of HMG-CoA reductase, a state that mimics long-term statin use, was associated with greater risk for developing cataract compared with individuals without genetic inhibition, researchers reported.
Statin prescriptions, LDL control low in patients before first ACS hospitalization
Fewer than 20% of patients who presented with ACS at a single center had LDL less than 70 mg/dL, according to data presented at the National Lipid Association Scientific Sessions.
NLA refines statin intolerance definition, management
The National Lipid Association updated its scientific statement on statin intolerance with a revised definition of statin intolerance and new guidance on how to manage patients with true or partial statin intolerance.