St Jude Childrens Research Hospital

Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed.

Cincinnati Children’s Hospital Medical Center has been ranked the No. 1 children’s hospital for cancer in the country.

Advances in pediatric cancer research and treatment over the past 50 years have led to dramatic improvements in survival outcomes for this vulnerable population.

Greg Armstrong, MD, MSCE, has been named chair of the department of epidemiology and cancer control at St. Jude Children’s Research Hospital.

Long-term childhood cancer survivors who maintained a healthy lifestyle with fewer modifiable heart disease risk factors had a 20% lower risk for mortality compared with those who did not, results of a retrospective study showed.

Rates of clonal hematopoiesis appeared higher among a cohort of pediatric cancer survivors compared with age-matched controls who never had cancer, according to study results published in Cancer Discovery.

Dual administration of CD19- and CD22-directed chimeric antigen receptor T cells conferred a 99% complete remission rate in younger patients with relapsed or high-risk B-cell acute lymphoblastic leukemia, phase 2 study results showed.

Survivors of childhood cancer are at risk for experiencing a high burden of long-term chronic health conditions, including high rates of obesity in adulthood, in part related to specific cancer treatments.

Patients who received the chemotherapy drug doxorubicin for childhood cancer and harbor a specific genetic mutation near the KCNK17 gene experienced significantly greater risk for heart disease later in life, study results have shown.

Researchers who identified proteins that influence T-cell formation have leveraged their discovery to develop a process that boosts the efficacy of chimeric antigen receptor T-cell therapy for solid tumors.