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Sickle Cell Disease

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October 28, 2023
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Life expectancy for people with sickle cell disease increases by a decade

Life expectancy for people with sickle cell disease increases by a decade

Life expectancy for individuals with sickle cell disease has increased by a decade since 2008, according to a study conducted by Epic Research.

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September 29, 2023
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Salmonella top cause of bacteremia among children with sickle cell disease


  <i>Salmonella</i> top cause of bacteremia among children with sickle cell disease

Salmonella — not Streptococcus pneumoniae — was the top cause of invasive bacterial infections among children with sickle cell disease in five European countries during a recent 6-year period, a study in Pediatrics reported.

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September 15, 2023
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Outreach increases COVID-19 vaccination among children with sickle cell disease

Outreach increases COVID-19 vaccination among children with sickle cell disease

Outreach efforts in the form of text messages and phone calls succeeded in increasing COVID-19 vaccination among children with sickle cell disease, according to a study published in Pediatrics.

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September 14, 2023
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National Sickle Cell Awareness Month: New insights into gene therapy, pain management

National Sickle Cell Awareness Month: New insights into gene therapy, pain management

September is National Sickle Cell Awareness Month.

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August 30, 2023
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Novel gene therapy offers ‘clinically meaningful improvement’ in sickle cell disease

Novel gene therapy offers &lsquo;clinically meaningful improvement&rsquo; in sickle cell disease

The first three patients who received an investigational gene therapy for sickle cell disease experienced dramatic reductions in complications related to sickle cell disease, according to results of a first-in-human study.

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August 11, 2023
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In vivo RNA-based gene editing shows potential for blood disorders

In vivo RNA-based gene editing shows potential for blood disorders

Researchers at Children’s Hospital of Philadelphia and Perelman School of Medicine at University of Pennsylvania developed an in vivo proof-of-concept model for the delivery of gene editing tools to treat blood disorders.

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July 31, 2023
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Despite safety concerns, gene therapies clinically beneficial for sickle cell disease

Despite safety concerns, gene therapies clinically beneficial for sickle cell disease

Evidence suggests two investigational gene therapies provide net health benefits compared with standard approaches for sickle cell disease, according to a revised evidence report from Institute for Clinical and Economic Review.

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July 20, 2023
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Novel gene editing cell therapy shows curative potential in sickle cell disease

Novel gene editing cell therapy shows curative potential in sickle cell disease

An experimental gene editing cell therapy for sickle cell disease has shown encouraging early results in a phase 1/phase 2 multicenter clinical trial, according to researchers at Cleveland Clinic Children’s.

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July 18, 2023
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Base-edited gene therapies ‘may be superior’ for sickle cell disease

Base-edited gene therapies &lsquo;may be superior&rsquo; for sickle cell disease

Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed.

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June 30, 2023
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Risk for bacteremia low among children with sickle cell disease, fever

Risk for bacteremia low among children with sickle cell disease, fever

The risk for bacteremia was low — just over 1% — among children and young adults with sickle cell disease who presented at the emergency department with a fever, according to the results of a large study published in JAMA Network Open.

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