Sickle Cell Disease
Life expectancy for people with sickle cell disease increases by a decade
Life expectancy for individuals with sickle cell disease has increased by a decade since 2008, according to a study conducted by Epic Research.
Salmonella top cause of bacteremia among children with sickle cell disease
Salmonella — not Streptococcus pneumoniae — was the top cause of invasive bacterial infections among children with sickle cell disease in five European countries during a recent 6-year period, a study in Pediatrics reported.
Outreach increases COVID-19 vaccination among children with sickle cell disease
Outreach efforts in the form of text messages and phone calls succeeded in increasing COVID-19 vaccination among children with sickle cell disease, according to a study published in Pediatrics.
National Sickle Cell Awareness Month: New insights into gene therapy, pain management
September is National Sickle Cell Awareness Month.
Novel gene therapy offers ‘clinically meaningful improvement’ in sickle cell disease
The first three patients who received an investigational gene therapy for sickle cell disease experienced dramatic reductions in complications related to sickle cell disease, according to results of a first-in-human study.
In vivo RNA-based gene editing shows potential for blood disorders
Researchers at Children’s Hospital of Philadelphia and Perelman School of Medicine at University of Pennsylvania developed an in vivo proof-of-concept model for the delivery of gene editing tools to treat blood disorders.
Despite safety concerns, gene therapies clinically beneficial for sickle cell disease
Evidence suggests two investigational gene therapies provide net health benefits compared with standard approaches for sickle cell disease, according to a revised evidence report from Institute for Clinical and Economic Review.
Novel gene editing cell therapy shows curative potential in sickle cell disease
An experimental gene editing cell therapy for sickle cell disease has shown encouraging early results in a phase 1/phase 2 multicenter clinical trial, according to researchers at Cleveland Clinic Children’s.
Base-edited gene therapies ‘may be superior’ for sickle cell disease
Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed.
Risk for bacteremia low among children with sickle cell disease, fever
The risk for bacteremia was low — just over 1% — among children and young adults with sickle cell disease who presented at the emergency department with a fever, according to the results of a large study published in JAMA Network Open.