Sickle Cell Disease
Extending antigen-matching protocols lowers odds for hemolytic disease of fetus, newborn
Extending routine donor-recipient matching to include Rhesus c, E and K antigens was tied to lower odds for hemolytic disease of the fetus and newborn vs. standard ABO blood type and Rhesus D antigen matching, researchers reported.
New molecule may help adults who do not respond to traditional sickle cell disease therapy
Researchers at Boston Medical Center identified a new small molecule that could benefit people with sickle cell disease who do not respond to hydroxyurea.
Hydroxyurea does not affect ovarian reserve of girls, young women with sickle cell disease
Hydroxyurea did not affect ovarian reserve among girls and young women with sickle cell disease, according to results published in Blood Advances.
World Sickle Cell Awareness Day: Gene therapy ‘transformative’
Today is World Sickle Cell Awareness Day.
Commentary: It’s in your DNA
It is almost impossible to pick up a medical journal today without seeing an article or commentary on gene editing.
Many children with sickle cell anemia do not receive recommended preventive care
Many children with sickle cell anemia do not receive guideline-concordant preventive care to reduce their risks for serious infections or stroke, according to research conducted at Children’s Hospital Los Angeles.
Exa-cel a ‘first step’ in gene therapy for sickle cell disease, beta-thalassemia
Exagamglogene autotemcel gave most patients with beta-thalassemia transfusion independence and drastically reduced the number of vaso-occlusive crises in those with sickle cell disease in a pair of phase 3 trials.
Study: Most US newborns with sickle cell disease are born in vulnerable areas
About two-thirds of newborns with sickle cell disease in the United States are born to mothers who live in counties with high or very high levels of social vulnerability, according to research findings published in MMWR.
CDC's opioid guidelines had unintended consequences for those with sickle cell disease
The release of the 2016 CDC guidelines for prescribing opioids for chronic pain may have had unintended consequences for patients with sickle cell disease, or SCD, a study showed.
Health professionals enthusiastic about approval of gene therapies for sickle cell disease
An analysis of online conversations among health care professionals on social media in December revealed collective enthusiasm following approval of the first two gene therapies for treatment of sickle cell disease.