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Sham Treatment

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April 01, 2025
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Gene therapy improves motor function in spinal muscular atrophy at 52 weeks

Intrathecal treatment with a vector-based gene therapy was associated with a greater improvement in motor function at 52 weeks compared with sham in patients aged 2 to 18 years with spinal muscular atrophy, data show.

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October 21, 2024
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Intracranial frequency stimulation linked to improved memory, cognition in Alzheimer’s

Results from a clinical trial examining intracranial stimulation using a novel device in those with mild Alzheimer’s disease showed that treatment led to improvements in memory, cognitive function and blood flow.

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October 17, 2024
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High dose of novel PD gene therapy linked to improved outcomes at 26 weeks

Topline data from a phase 2 clinical trial of an investigational gene therapy for Parkinson’s disease showed that a higher dose of the medication significantly improved disease-specific and quality of life measures by week 26.

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July 20, 2023
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No significant improvement in cognition with active vs. sham transcranial stimulation

Researchers reported no significant difference in cognitive performance between active and sham transcranial direct current stimulation for mild cognitive impairment, per a poster at the Alzheimer’s Association International Conference.