Severe Aortic Stenosis
Dapagliflozin benefits older patients with heart failure undergoing valve replacement
CHICAGO — The first trial to evaluate use of an SGLT2 inhibitor in people undergoing transcatheter aortic valve replacement showed benefit with dapagliflozin compared with standard care alone, including in older patients.
Routine cerebral embolic protection shows no benefit for patients undergoing TAVR
CHICAGO — Routine cerebral embolic protection did not reduce the incidence of stroke at 72 hours in patients undergoing transcatheter aortic valve replacement, according to results of the BHF PROTECT-TAVI trial.
Aortic valve replacement benefit uncertain in asymptomatic disease with myocardial fibrosis
WASHINGTON — Among patients with asymptomatic severe aortic stenosis and myocardial fibrosis, transcatheter or surgical aortic valve replacement did not improve outcomes compared with guideline-directed conservative management.
Long-term mortality, stroke similar in TAVR vs. surgery, but need for pacemaker elevated
Transcatheter aortic valve replacement was associated with similar long-term mortality and stroke risk vs. surgery for severe aortic stenosis, but with greater risk for pacemaker implant with self-expanding TAVR valves, a speaker reported.
TAVR equal to surgery in younger low-risk patients, but not if they have bicuspid valves
In younger patients with severe aortic stenosis at low surgical risk, transcatheter aortic valve replacement was associated with similar outcomes to surgical AVR, except in those with bicuspid valves, researchers reported.
In women with small aortic annuli, TAVR with self-expanding valve has better hemodynamics
In women with severe aortic stenosis and small aortic annuli who underwent transcatheter aortic valve replacement, a self-expanding valve was linked with better hemodynamic outcomes vs. a balloon-expandable valve at 1 year.
Percutaneous treatment of severe aortic stenosis, complex CAD superior vs. surgery
A percutaneous approach to treatment of severe aortic stenosis and complex CAD was superior to surgical valve replacement and CABG, a speaker reported.
New class of biomimetic TAVR valve safe, feasible for severe aortic stenosis
In a first-in-human study, a new class of transcatheter heart valve demonstrated good safety and restored aortic blood flow to levels similar to a healthy aortic valve at 1 year, a speaker reported.
TAVR noninferior to surgery in real-world lower-risk patient population
ATLANTA — In a real-world population of patients with severe aortic stenosis at low or intermediate surgical risk, transcatheter aortic valve replacement was noninferior to surgery for death and stroke at 1 year, researchers reported.
Early-generation TAVR valve shows durable results in high-risk patients at 5 years
Pooled 5-year data of an intra-annular self-expanding transcatheter heart valve in patients with severe aortic stenosis at high surgical risk showed good indicators of durability, researchers reported.