Sepsis

Patients who develop early hyponatremia after starting thiazide diuretics have a higher mortality risk than those with normal sodium levels, according to retrospective study data.

Febrile infants aged 22 to 60 days were less likely to be hospitalized or receive antibiotics after the AAP published updated recommendations for their management, according to a study published in Pediatrics.

In the U.K., the proportion of ICU patients with sepsis who died in a hospital was smaller in 2017 to 2019 vs. 1988 to 1990, according to results published in American Journal of Respiratory and Critical Care Medicine.

Healio has compiled the most-read news in pulmonology posted in October.

The proportion of children dying from sepsis is lower than it was 20 years ago, but Black children are still at a significantly higher risk than white children, according to a study presented at IDWeek.

Among adult sepsis survivors readmitted within 30 days, more than two-thirds had been previously discharged to a skilled nursing facility, home health care or home, according to results published in American Journal of Critical Care.

Without improvements to access and delivery of health care, more than 39 million people may die because of antimicrobial-resistant bacterial infections between 2025 and 2050, according to new estimates.

With earlier receipt of antibiotics for sepsis, those with vs. without metastatic cancer or shock had larger reductions in 30-day mortality, according to results published in American Journal of Respiratory and Critical Care Medicine.

Adults treated in EDs with established sepsis alert systems benefited from reduced mortality risk and length of hospitalization compared with facilities with no alert system, according to data published in JAMA Network Open.

De-escalation of beta-lactam antibiotics was associated with a decreased risk of new resistance development compared with no change in beta-lactam antibiotic use, researchers found.