Scleroderma
Systemic sclerosis diagnoses clustered around Superfund sites
Systemic sclerosis appears to have a “non-random” occurrence across the United States, with clusters of people diagnosed around environmentally contaminated Superfund sites, according to data published in Arthritis Care & Research.
Frailty in systemic sclerosis increases mortality risk nearly 10 times
Frailty among patients with systemic sclerosis significantly increases the risk for mortality by nearly 10-fold, but shows the potential to improve over time, according to data published in Clinical Rheumatology.
Botulinum toxin reduces pain, disability in Raynaud’s syndrome secondary to scleroderma
Botulinum toxin injections in the hand led to significant reductions in pain and disability for patients with Raynaud’s syndrome secondary to scleroderma, according to data published in Clinical Rheumatology.
CAR T therapy shows ‘no major hematotoxicites’ in autoimmune disease phase 1/2 study
WASHINGTON — A phase 1/2 study of CD19 chimeric antigen receptor T-cell therapy in lupus and other autoimmune diseases demonstrated significant response with minimal toxicities, according to data presented at ACR Convergence 2024.
‘Treat what is treatable’: Organ specific approach key for systemic sclerosis management
SAN DIEGO — Clinicians managing systemic sclerosis should focus on treating “what is treatable” in each organ that is involved, according to data presented at the 2024 Congress of Clinical Rheumatology West.
All patients with systemic sclerosis require screening for interstitial lung disease, PAH
SAN DIEGO — All patients with systemic sclerosis should be screened for pulmonary arterial hypertension and interstitial lung disease, according to a speaker at the 2024 Congress of Clinical Rheumatology West.
Severe disease, strict endpoints in CAR T trials 'could be a way through the regulators'
SAN DIEGO — Regulatory trials of chimeric antigen receptor T-cell therapies for autoimmune diseases could be successful with a focus on patients with severe disease and strict endpoints, according to a speaker.
Severe toxicity risk from radiotherapy ‘may not be trivial’ in systemic sclerosis
Radiotherapy poses no significant risks for worsening disease in patients with systemic sclerosis, but entails “variable risk” for both acute and late toxicities, according to data published in The Journal of Rheumatology.
Collaborative systemic sclerosis care comes with challenges, but improves outcomes
ORLANDO, Fla. — Including multiple specialists to treat the various facets of systemic sclerosis improves outcomes but can have its own challenges, according to a presenter at the 2024 Rheumatology Nurses Society annual conference.
Internal organ involvement ‘much more’ common in late-onset systemic sclerosis
Internal organ, heart and kidney involvement, as well as pulmonary arterial hypertension, are “much more” common in cases of systemic sclerosis that develop after age 60 years, according to data published in Clinical Rheumatology.