Schizophrenia

Cross-generational bipolar disorder transmission appeared to be caused largely by genes, with rearing effects having a modest role, according to results of an extended Swedish national adoption study published in JAMA Psychiatry.

Schizophrenia clinical trials have exhibited a trend of increasing placebo responses and decreasing treatment effects over a 24-year period, particularly North American trials, according to study results published in Journal of Clinical Psychiatry.

A combination of olanzapine and samidorphan demonstrated clinically significant efficacy improvements compared with placebo among adults with acutely exacerbated schizophrenia, according to results of the randomized, phase 3 ENLIGHTEN-1 study published in Journal of Clinical Psychiatry. The treatment, ALKS 3831 (Alkermes), also appeared well-tolerated.

An individualized treatment rule may increase the treatment success rate of patients with first-episode schizophrenia, according to study results published in JAMA Network Open. However, researchers noted the necessity of a clinical trial and replication of these results with an expanded predictor set before clinical implementation.

Researchers have found evidence countering the hypothesis that a long duration of untreated psychosis is associated with “insidious, severe psychotic disorder,” as well as against the toxicity of untreated psychosis, according to study findings published in American Journal of Psychiatry.

Researchers have identified psychosis subgroups that may inform ongoing efforts to redefine psychosis taxonomy using updated criteria, according to results of a longitudinal cohort study published in JAMA Psychiatry.

Healio Psychiatry has compiled a list of the top five most-viewed stories in January.

The FDA issued a new safety communication announcing a strengthened warning about the risks of untreated constipation among patients who receive clozapine.

Researchers have found lower levels of a protein associated with neural connections in the living brains of people with schizophrenia, according to results of parallel clinical and preclinical studies published in Nature Communications.

An interactive voice response system that uses artificial intelligence effectively monitored the well-being of patients with serious mental illness, according to study findings published in PLOS One.