Schizophrenia

The FDA has approved the supplemental new drug application for Rexulti for treating schizophrenia in patients aged 13 to 17 years, Otsuka and Lundbeck announced.

Using polygenic risk scores to determine likelihood of parental bipolar disorder passing to offspring is promising but unproven, according to a community-based case-control longitudinal study published in JAMA Psychiatry.

Patients with personality disorders experienced worsened symptoms, some of which have not improved, during the COVID-19 pandemic, according to an observational retrospective study published in Psychiatry Research.

Healio Psychiatry’s five most-viewed stories of the year highlight a study on omega-3 supplementation and stress-related accelerated aging, research into the benefits of cannabidiol for frontline health care workers and data on the link between OCD and increased risk for dementia/Alzheimer’s disease.

Individuals with schizophrenia who died by suicide were more likely to be older, have previous suicide attempts and be women, according to data published in Psychiatry Research.

Results of a 5-year study in Japan suggest pulmonary embolism may be a major cause of sudden cardiac arrest among patients with psychiatric disorders.

A single-arm, single-blind, phase 2a study of the neuromodulating drug RL-007, initiated by biopharmaceutical company atai Life Sciences, revealed its effectiveness in improving cognitive function and awareness in patients with schizophrenia.

Areas with high levels of social fragmentation had higher rates of psychosis, according to results of a systematic review published in Journal of Clinical Psychiatry.

FDA recently approved Lybalvi for the treatment of schizophrenia and for use in manic and mixed (depressive and manic) episodes of bipolar I disorder as an acute treatment, a maintenance treatment, and for use with valproate or lithium.

A 26-week, randomized, double-blind, placebo-controlled phase 2 study showed pimavanserin reduced negative schizophrenia symptoms in stable patients.