Sarcopenia
Sarcopenia unlikely for most after weight loss, but more data needed on older adults
Most adults who lose weight as part of obesity therapy should not experience sarcopenia due to a decrease in fat-free mass, but more research is needed on the impact of GLP-1 receptor agonists and similar drugs on older adults.
FDA fast tracks Lipocine’s oral androgen receptor agonist for sarcopenia in cirrhosis
The FDA granted fast track designation to Lipocine’s LPCN 1148, an oral androgen receptor agonist containing testosterone dodecanoate, for the treatment of sarcopenia in patients with decompensated cirrhosis, according to the manufacturer.
Frailty negatively impacts lung function, survival in patients with IPF
Significant predictors of FVC and diffusion capacity of lung for carbon monoxide included frailty, low fat-free mass index and sarcopenia in patients with idiopathic pulmonary fibrosis, according to data published in Respiratory Research.
Positive trial of ponsegromab may signal ‘start of a revolution’ for cancer cachexia
A randomized phase 2 trial of individuals with cancer cachexia showed those assigned ponsegromab gained significantly more weight than those assigned placebo.
Oral androgen receptor agonist improves sarcopenia over 52 weeks in men with cirrhosis
LPCN 1148, an oral androgen receptor agonist, improved sarcopenia in men with advanced cirrhosis as early as week 12 — with sustained improvement through 52 weeks — and reduced recurrence of encephalopathy, according to late-breaking data.
Premature surgical menopause tied to musculoskeletal discomfort, sarcopenia risk
Premature surgical menopause may increase the likelihood of musculoskeletal discomfort and sarcopenia, highlighting the potential importance of hormones in postmenopausal musculoskeletal health, researchers reported in Menopause.
Oral androgen receptor agonist improves sarcopenia, encephalopathy in cirrhosis
BOSTON — LPCN 1148, an oral androgen receptor agonist, improved sarcopenia, hepatic encephalopathy and other biomarkers associated with end-stage liver disease among men with advanced cirrhosis and clinical decompensation.
Sarcopenia prevalence high with HFrEF, predicts adverse outcomes
Sarcopenia significantly increases risk for adverse outcomes in adults with HF with reduced ejection fraction, including death and rehospitalization, as well as risk for falls and hospitalization, researchers reported.
Lack of protein negatively impacts skeletal muscle mass recovery after kidney transplant
Protein intake positively correlated with recovery of skeletal muscle mass in kidney transplant recipients, according to a study in Clinical Nutrition.
Sarcopenia more prevalent among menopausal women without vasomotor symptoms
Menopausal women experiencing vasomotor symptoms are less likely to have sarcopenia compared with those who do not have vasomotor symptoms, according to a study published in Menopause.