Renin-Angiotensin System

Patients with chronic kidney disease who were initiated on renin-angiotensin system inhibitors experienced greater benefits, including a reduced need for dialysis, than those initiated on calcium channel blockers.

An analysis of the VICTORIA trial showed that the benefits of vericiguat in HF with reduced ejection fraction was consistent across various background therapies for HFrEF, a speaker reported.

Use of renin-angiotensin-aldosterone system, or RAAS, antagonists such as ACE inhibitors or angiotensin receptor blockers was linked to reduced risk for colorectal cancer in the 3 years after an index colonoscopy with negative diagnosis.

Emerging data suggest that renin-angiotensin-aldosterone system, or RAAS, antagonists do not worsen outcomes of COVID-19, confirming recommendations released in March by various cardiology societies that patients who become infected with the coronavirus while receiving RAAS antagonists should continue to take them. This was the top story in cardiology last week.

ACE inhibitors and angiotensin II receptor antagonists did not affect the severity of or mortality from COVID-19 in patients with hypertension who were hospitalized for the disease, according to a brief report published in JAMA Cardiology.

CHICAGO — In this video exclusive, Cardiology Today Editorial Board Member Ileana L. Piña, MD, MPH, discussed her Cardiometabolic Health Congress workshop on the role of potassium-binding agents in optimizing guideline-directed therapy for HF.

Neurohormonal therapies for the prevention of cardiotoxicity in patients who received chemotherapy conferred improvements in left ventricular ejection fraction as well as left ventricular strain, but benefits were minor and may be within inter-test variability of measurement, researchers reported.

PARIS — New data from the SWEDEHEART registry presented at the European Society of Cardiology Congress show that use of statins, antiplatelet therapies and renin-angiotensin-aldosterone system inhibitors yields reduced risk for mortality after CABG.

PARIS — Among a cohort of patients with stable CAD, angina yielded worse outcomes in patients with prior MI but did not make a difference in patients without prior MI, according to results from the CLARIFY registry presented at the European Society of Cardiology Congress.

HF remains a complex clinical syndrome. It is estimated that nearly 6 million Americans have HF and more than 800,000 new cases of HF are diagnosed annually in the United States.