Relapse

Patients with Crohn’s disease who stopped infliximab had a significantly higher risk of relapse vs. those who continued combination therapy, according to results presented at the Congress of the European Crohn’s and Colitis Organization.

Dimethyl fumarate and fingolimod appeared to have no significant difference in relapse rates, and rituximab appeared to have better relapse outcomes than natalizumab in patients with MS, according to results published in JAMA Network Open.

Higher end-of-treatment hepatitis B e-antigen level correlated with nucleos(t)ide clinical relapse but did not correlate with relapse severity regardless of HBsAg level among patients with chronic hepatitis B virus, according to research.

Patients in primary care practices who “felt well enough” to stop certain antidepressants — and did so — were at higher risk for relapse of depression by 52 weeks compared with those who continued therapy, researchers wrote.

Researchers identified a correlation between low doses of antipsychotics and relapse prevention in schizophrenia, according to findings published in JAMA Psychiatry.

Axsome Therapeutics’ AXS-05 achieved the primary endpoint of significantly delaying time to relapse of depression in patients with treatment-resistant depression in a phase 2 trial, according to a company press release.

Using circulating tumor DNA to predict relapse after autologous stem cell transplantation in patients with multiple myeloma showed feasibility in a study presented at the virtual ASCO Annual Meeting.

Cigarette use was linked to increased onset and persistence of and relapse to cannabis use disorder 3 years later among adults, according to study results published in Journal of Clinical Psychiatry.

Long-acting injectable antipsychotics provided significant benefit in prevention of hospitalization or relapse for schizophrenia compared with oral antipsychotics, according to study results published in The Lancet Psychiatry.

Mindfulness-based cognitive therapy may offer protection against depressive relapse, according to study results published in Counselling & Psychotherapy Research.