Psychosis
Obstetric complications, psychiatric history, lower IQ linked to early-onset psychosis
Premorbid factors including obstetric complications, personal psychiatric background and IQ may help predict which patients are at increased risk for early-onset psychosis, according to study results.
Dementia-related psychosis treatments fail to meet patients’ needs
Patients with dementia-related psychosis self-reported severe symptoms that were not reduced by current treatments, according to findings published in Clinical Gerontologist.
Real-world data support early intervention for patients with first-episode psychosis
Pimavanserin lowers relapse risk in patients with dementia-related psychosis
In a phase 3 trial of pimavanserin that came to a premature halt for efficacy, patients with dementia-related psychosis who continued the treatment had a lower risk for relapse than those who were switched to placebo, researchers reported.
25% of people at clinical high risk for psychosis develop the disorder within 3 years
One-fourth of people at clinical high risk for psychosis developed psychosis within 3 years, according to results of an updated meta-analysis published in JAMA Psychiatry.
Cognitive therapy program reduces persistent delusions in non-affective psychosis
A theoretically driven cognitive therapy program significantly reduced persistent persecutory delusions compared with a befriending intervention among patients with non-affective psychosis.
Functional dysconnectivity 'widespread' in antipsychotic-naive first-episode psychosis
Antipsychotic-naive patients with first-episode psychosis exhibited widespread functional dysconnectivity at baseline, according to results of a secondary analysis of a randomized clinical trial published in JAMA Psychiatry.
Novel digital intervention improves vocational attainment in first-episode psychosis
Algorithm predicts risk for incident metabolic syndrome in young people with psychosis
Researchers have developed an algorithm tailored to age that can predict the risk for incident metabolic syndrome among young people with psychosis, according to study results published in The Lancet Psychiatry.
Lower cortical thickness measures may indicate clinical high risk for psychosis
Widespread subtle, lower cortical thickness measures were associated with clinical high risk for psychosis, according to results of a working-group mega-analysis published in JAMA Psychiatry.