Psychosis

A phase 2 clinical trial has been initiated to evaluate the safety and efficacy of an inverse agonist for hallucinations and delusions associated with Alzheimer’s disease psychosis, according to the manufacturer.

A psychological sleep intervention reduced severity of insomnia and mental health symptoms as early as 3 months in young people at ultra-high risk for psychosis and warrants further study, according to research in The Lancet Psychiatry.

Adults who developed diabetes, psychosis and congestive HF, in that order, had reduced life expectancy compared with people who developed the same three conditions in a different order, researchers reported.

Existing treatments for patients with an ultrahigh risk of psychosis offer relatively poor responsiveness, underscoring a need for further innovation in relapse prevention, according to a study published in JAMA Psychiatry.

In children with familial high risk of schizophrenia or bipolar disorder, evidence of motor impairment skills may indicate neurodevelopmental vulnerability for psychosis.

Sleep disturbances were found to be prevalent throughout the course of psychosis, and different psychosis stages showed shared and distinct abnormalities, researchers reported in JAMA Psychiatry.

Accurate prediction tools can be developed for people with first episodes of psychosis, which could potentially help clinician decision-making, researchers reported in JAMA Psychiatry.

Environmental factors play a greater role in the genesis of psychotic experiences than genetic factors among adolescents, according to a study published in JAMA Psychiatry.

The FDA has declined to approve a supplemental new drug application for the expanded use of Nuplazid to treat psychosis related to Alzheimer's disease.