Progestin

BOSTON — In a phase 2b trial, a hormonal contraceptive gel for use by men worked faster than expected, suppressing sperm count to effective levels by week 8 of use, making it an “attractive” product, according to a speaker at ENDO 2024.

In the first years of use, women prescribed conjugated estrogens/bazedoxifene vs. estrogen/progestin for menopausal symptoms may have higher rates of endometrial cancer and endometrial hyperplasia but lower breast cancer rates.

PHILADELPHIA — The number of women aged at least 50 years prescribed hormone therapy for menopause symptoms remains low, particularly for Hispanic women, despite good efficacy and safety, according to a presenter.

For premenopausal women with endometrial intraepithelial neoplasia, use of conservative treatment with progestin increased and hysterectomy declined from 2008 to 2020, researchers reported.

The FDA “appears poised” to withdraw the only drug indicated for the prevention of preterm birth from the market following a recent recommendation to do so.

Over-the-counter progestin-only pills may provide the benefits of other contraceptives while eliminating substantial barriers to access, according to a survey of participants in a study of OTC progestin-only pills.

The FDA Obstetrics, Reproductive and Urologic Drugs Advisory Committee voted 14-1 to remove a drug indicated for preventing preterm birth from the market due to lack of effectiveness.

Use of combined oral contraceptives in women with obesity may confer elevated CV risk in the form of venous and arterial thromboembolism, researchers reported.

During the past 2 decades, Endocrine Today has reported on the latest developments in hormone therapy for symptoms associated with menopause. For its 20th year, the publication is taking a look back.

About 14,000 women each year die of ovarian cancer, making it one of the deadliest gynecologic cancers.