Polygenetic And Multifactorial Disease

Rare and common genetic variants contribute substantially to susceptibility to hypertrophic cardiomyopathy in the general population and can help improve risk prediction beyond clinical factors, researchers reported.

A genomic approach may help identify children at high risk for suicidal thoughts and behaviors, according to results of a cohort study published in JAMA Network Open.

Family genetic risk scores showed clear separations between major affective and psychotic disorders and were linked to early age at onset and high rates of recurrence, according to results of a Swedish cohort study published in JAMA Psychiatry.