Plasma

Quanterix Corp. announced it has partnered with the Alzheimer’s Drug Discovery Foundation to accelerate the development of a multi-analyte plasma test for early detection of Alzheimer’s disease.

Phase 3 study results of lumasiran to treat advanced primary hyperoxaluria type 1 showed a significant reduction in plasma oxalate and “pre-dialysis” plasma oxalate from baseline to 6 months, a speaker at ASN Kidney Week said.

Increased levels of neurofilament light in plasma samples correlated with a greater risk for ALS, according to findings from an analysis of plasma samples obtained within 5 years of an ALS diagnosis that was published in Neurology.

Decreased levels of plasma amyloid beta 42 at midlife, but not late life, correlated with an increased risk for dementia and a “marginally higher” risk for mild cognitive impairment, according to findings published in Neurology.

Among patients with non-ST-segment elevation ACS, a higher relative proportion of plasma long-chain omega-3 polyunsaturated fatty acid was associated with lower chances of sudden cardiac death, researchers reported.

Platelet-rich plasma and concentrated bone marrow aspirate injections had similar outcomes for treatment of knee osteoarthritis at 24-month follow-up, according to results.

The NIH announced that it is ending a clinical trial evaluating the safety and effectiveness of COVID-19 convalescent plasma in ED patients with mild to moderate symptoms.

Plasma levels of interleukin-1 receptor antagonist correlated with cerebrospinal fluid neurofilament light levels and predicted disability among patients with MS, according to a study presented at the ACTRIMS virtual meeting.

An analysis of 51 plasma proteins associated with immune response identified four proteins capable of confirming a recent epileptic seizure or a psychogenic non-epileptic seizure, according to findings published in Neurology.

Recruitment for the convalescent plasma arm of the RECOVERY trial was closed after an independent board determined there was no evidence the treatment benefited patients with COVID-19, according to the trial’s chief investigators.