Placebo

Terns Pharmaceuticals Inc. announced initiation of a phase 1b clinical trial assessing TERN-201 for the treatment of patients with nonalcoholic steatohepatitis.

The placebo effect on pain scores in osteoarthritis may be attributed to a phenomenon called “regression to the mean,” according to a speaker at the 2021 OARSI World Congress.

Treatment with Vyepti during a migraine provided earlier freedom from headache pain and most bothersome migraine symptoms — either photophobia, phonophobia or nausea — compared with placebo, according to results from the RELIEF study.

Atorvastatin 20 mg daily vs. placebo in patients who had reported muscle-related side effects from statins.

Atorvastatin demonstrated no overall effect on the frequency or severity of muscle symptoms among individuals who previously reported severe muscle symptoms while on statins, compared with placebo, according to data published in The BMJ.

Statins and placebo triggering symptoms in patients with past statin intolerance.

Patients who developed symptoms within 2 weeks of statin initiation reported similar side effects while on placebo, suggesting a large proportion of burden owed to the nocebo effect, according to findings from the SAMSON trial.

Participants in rheumatoid arthritis clinical trials who received a placebo exhibited meaningful gains in objective and subjective outcomes, indicating that placebo responses represent more than a psychological effect, researchers noted.

Coformulated, fixed-dose sodium phenylbutyrate–taurursodiol reduced the rate of functional decline compared with placebo in patients with amyotrophic lateral sclerosis, or ALS, according to findings from the CENTAUR study.

Oral curcumin was no more effective than placebo for preventing Crohn’s disease recurrence among patients who underwent surgery for Crohn’s, according to study results.