Placebo

Long-term supplementation with spermidine improved neither memory function nor biomarkers compared with placebo in older adults with subjective cognitive decline, according to results of a clinical trial published in JAMA Network Open.

Compared with placebo, oral methylprednisolone treatment reduced the risk of kidney function decline among patients with IgA nephropathy at high risk of progression, according to data published in JAMA.

Pediatric patients on hemodialysis may benefit from L-carnitine supplementation due to the potential benefits it may have on inflammation and cardiovascular events, according to data published in the Journal Renal Nutrition.

Researchers report it is feasible to recruit and retain acute kidney transplant recipients in trials examining prebiotics on infections and gastrointestinal symptoms, according to data published in the Journal of Renal Nutrition.

Open-label placebo reduced pain and rescue medication use among pediatric and adolescent patients with functional abdominal pain and irritable bowel syndrome, according to research published in JAMA Pediatrics.

A 26-week, randomized, double-blind, placebo-controlled phase 2 study showed pimavanserin reduced negative schizophrenia symptoms in stable patients.

The investigational drug, bardoxolone methyl preserved kidney function in patients and provided eGFR benefits for those with chronic kidney disease, according to an oral abstract presentation given as part of ASN Kidney Week.

Randomized clinical trials of antidepressants often contain placebo run-in periods despite their apparent lack of benefits to outcome, according to results of a systematic review and meta-analysis published in JAMA Psychiatry.

Steroids can reduce the risk of major kidney outcomes and kidney failure in patients with high-risk IgA nephropathy, according to data presented at ASN Kidney Week.

Azstarys significantly improved ADHD symptoms in children aged 6 to 12 years vs. placebo, according to results of a randomized, controlled laboratory classroom study published in Journal of Child and Adolescent Psychopharmacology.