Phenotype
Nasal samples identify asthma endotypes among minoritized youth
Most youths with asthma had T17HIGH and T2LOW/T17LOW endotypes of the disease based on transcriptomic profiles of nasal epithelium, according to a study published in JAMA.
Disease activity, symptom burden can indicate Sjögren’s treatment strategy
SAN DIEGO — Determining which of several phenotypes a patient with Sjögren’s disease falls under can help inform their treatment strategy, according to data presented at the 2024 Congress of Clinical Rheumatology West.
Q&A: Phenotype test predicting semaglutide response could ‘change conversation’ on obesity
In a Healio exclusive, Andres J. Acosta, MD, PhD, highlights data demonstrating that the MyPhenome test may serve as a biomarker to determine whether a patient with obesity will be a “good responder” to semaglutide.
Childhood obesity linked to higher risk for most type 2 diabetes subtypes in adulthood
People with a genetic risk factor for childhood obesity have increased likelihood of developing most subtypes of type 2 diabetes as adults, according to findings from a Mendelian randomization published in Diabetologia.
Phenotypes of lung function impairment in patients with sarcoidosis vary by race, sex
Patients with sarcoidosis of different races and sexes had differing frequencies of lung function impairment phenotypes, according to study results published in Annals of the American Thoracic Society.
Older Black adults with acute MI more likely to present with ‘geriatric’ phenotype
Among adults hospitalized with acute MI, Black patients presented with a more “geriatric” phenotype with more functional impairments than white patients despite being younger, researchers reported.
Researchers propose algorithm to assess kidney transplant injury phenotypes, severity
A data-driven algorithm, RejectClass, may provide a “holistic and quantitative” measurement of kidney transplant injury phenotypes and severity, according to investigators.
Different phenotypes drive early, late onset asthma
Early onset persistent asthma and late onset asthma have distinct phenotypes with different features and comorbidities impacting disease control, according to a study published in The Journal of Allergy and Clinical Immunology: In Practice.
Chest CT imaging phenotypes may explain COPD heterogeneity
CT measurements may support patient satisfaction along the continuum of COPD phenotypes, and imaging phenotypes could explain a proportion of COPD heterogeneity, researchers reported in Annals of the American Thoracic Society.
Phenotypes, early-life factors characterize difficult-to-control asthma in urban children
PHOENIX — Certain phenotypes are associated with difficult-to-control asthma in urban children, which may be characterized by specific early-life factors and patterns of nasal epithelial cell gene expression, according to a speaker here.