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Pediatric Oncology

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April 20, 2022
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CAR-T ‘robustly effective’ in younger patients with deadly form of brain cancer

CAR-T ‘robustly effective’ in younger patients with deadly form of brain cancer

Younger patients with diffuse midline glioma experienced prolonged clinical improvement after receiving an investigational chimeric antigen receptor T-cell therapy, study results demonstrated.

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April 18, 2022
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Genetic ancestry associated with molecular subtypes, prognosis of childhood ALL

Genetic ancestry associated with molecular subtypes, prognosis of childhood ALL

Acute lymphoblastic leukemia molecular subtypes and prognosis appeared associated with genetic ancestry, suggesting a possible genetic basis for racial and ethnic disparities in ALL, according to a study in JAMA Oncology.

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April 15, 2022
5 min read
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Oncologist to run his 30th Boston Marathon with vision of ‘curing all children with cancer’

Oncologist to run his 30th Boston Marathon with vision of ‘curing all children with cancer’

Besides making sure each foot lands in front of the other, there isn’t much you can do during a 26.2-mile run other than let your mind wander.

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April 13, 2022
3 min read
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Subset of Latino children with acute lymphoblastic leukemia may have higher relapse risk

Subset of Latino children with acute lymphoblastic leukemia may have higher relapse risk

Among children diagnosed with acute lymphoblastic leukemia, Latinos without minimal residual disease had a higher likelihood of relapse than their white counterparts, according to study results.

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April 12, 2022
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Certain genetic patterns may predict response to CAR-T for acute lymphoblastic leukemia

Certain genetic patterns may predict response to CAR-T for acute lymphoblastic leukemia

Younger patients with acute lymphoblastic leukemia who do not respond to CD19-directed chimeric antigen receptor T-cell therapy exhibit certain gene regulation patterns that may be associated with treatment resistance, study results show.

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April 11, 2022
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Children with cancer in low-, middle-income nations at higher risk for death amid pandemic

Children with cancer in low-, middle-income nations at higher risk for death amid pandemic

Children with cancer who reside in low- and- middle-income countries had a higher risk for mortality due to any cause than those in high-income countries during the first 9 months of the COVID-19 pandemic, according to study results.

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April 11, 2022
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RACE Act led to more required pediatric studies of cancer drugs

RACE Act led to more required pediatric studies of cancer drugs

The Research to Accelerate Cures and Equity Act led to an increase in required pediatric studies for recently approved cancer therapies within the first year of the act’s implementation, according to study results.

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April 04, 2022
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‘Multidisciplinary approach needed’ to boost AYA participation in cancer clinical trials

‘Multidisciplinary approach needed’ to boost AYA participation in cancer clinical trials

Clinical trials play an important role in developing and evaluating potential new cancer therapies.

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March 31, 2022
6 min read
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Lack of awareness, limited sites hinder CAR-T trials for younger patients with cancer

Lack of awareness, limited sites hinder CAR-T trials for younger patients with cancer

The FDA’s approval of tisagenlecleucel in 2017 resulted in an explosion of research into chimeric antigen receptor T-cell therapies.

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March 30, 2022
2 min read
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Pandemic profoundly impacts pediatric oncology providers

Pandemic profoundly impacts pediatric oncology providers

The COVID-19 pandemic substantially affected the pediatric oncology workforce, leading to physical, psychological and financial strain, according to results of a survey study published in Cancer.

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