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Pediatric Oncology

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November 10, 2022
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CAR-T effective for younger patients with leukemia, regardless of socioeconomic status

CAR-T effective for younger patients with leukemia, regardless of socioeconomic status

Socioeconomic status had no impact on complete remission rates or overall survival among younger patients who received chimeric antigen receptor T-cell therapy for B-cell acute lymphoblastic leukemia, study results showed.

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November 08, 2022
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CAR-T regimen ‘should be new standard’ for high-risk B-cell acute lymphoblastic leukemia

CAR-T regimen ‘should be new standard’ for high-risk B-cell acute lymphoblastic leukemia

Dual administration of CD19- and CD22-directed chimeric antigen receptor T cells conferred a 99% complete remission rate in younger patients with relapsed or high-risk B-cell acute lymphoblastic leukemia, phase 2 study results showed.

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July 22, 2022
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‘This is amazing’: New tool can help assess clinical impact of somatic cancer mutations

‘This is amazing’: New tool can help assess clinical impact of somatic cancer mutations

Next-generation sequencing and precision medicine techniques have enabled the identification of millions of somatic cancer variants.

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June 29, 2022
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Oncolytic adenovirus shows potential in pediatric diffuse intrinsic pontine glioma

Oncolytic adenovirus shows potential in pediatric diffuse intrinsic pontine glioma

The oncolytic adenovirus DNX-2401 appeared safe and feasible among a small cohort of pediatric patients with diffuse intrinsic pontine glioma, according to study results published in The New England Journal of Medicine.

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June 29, 2022
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Cancer cell therapy innovator shifts focus toward treatment of solid tumors

Cancer cell therapy innovator shifts focus toward treatment of solid tumors

Crystal L. Mackall, MD, believes she has an "unusual pedigree" for someone in her position.

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June 23, 2022
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Genomic profiling of pediatric tumors after relapse may widen treatment options

Genomic profiling of pediatric tumors after relapse may widen treatment options

Genomic sequencing of tumors enabled 107 patients with pediatric cancer who experienced relapse to receive an appropriate matched therapy that is not standard of care, according to study results reported in Cancer Discovery.

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June 22, 2022
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Study reveals disparities in end-of-life care for children with cancer

Study reveals disparities in end-of-life care for children with cancer

Emily E. Johnston, MD, MS, prides herself on being there for her pediatric oncology patients at every step of their cancer journeys.

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June 19, 2022
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Onkos Surgical to acquire Stryker’s Juvenile Tumour System for pediatric bone cancer

Onkos Surgical Inc. has announced a definitive agreement with Stryker for the acquisition of the Juvenile Tumour System, an extendible prosthesis system for pediatric patients with bone cancer, according to an Onkos Surgical press release.

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June 12, 2022
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Intramuscular recombinant Erwinia asparaginase active, safe in leukemia, lymphoma subsets

Intramuscular recombinant <i>Erwinia</i> asparaginase active, safe in leukemia, lymphoma subsets

A phase 2/phase 3 study assessed intramuscular asparaginase Erwinia chrysanthemi (recombinant)-rywn for patients with acute lymphoblastic leukemia or lymphoblastic lymphoma who developed hypersensitivity to E. coli-derived L-asparaginase.

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June 09, 2022
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Brentuximab regimen effective for younger patients with advanced-stage Hodgkin lymphoma

Brentuximab regimen effective for younger patients with advanced-stage Hodgkin lymphoma

CHICAGO — Combining brentuximab vedotin with a chemotherapy regimen as first-line therapy conferred an objective response in 88% of younger patients with newly diagnosed advanced-stage classical Hodgkin lymphoma, study results show.

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