Pancreatic Cancer

BARCELONA, Spain — Four months of induction combination chemotherapy followed by surgical exploration made secondary resection feasible for about one-third of patients with nonresectable locally advanced pancreatic cancer, according to results of the randomized phase 2 NEOLAP trial presented at European Society for Medical Oncology Congress.

Patients with pancreatic cancer who received neoadjuvant therapy before pancreatoduodenectomy exhibited biliary microbiome alterations, according to study results.

Among the top stories in endocrinology last week were the FDA’s decision to fast track the sodium-glucose cotransporter 2 inhibitor dapagliflozin to delay renal failure in patients with or without diabetes who also have with chronic kidney disease and a study that found adults with type 2 diabetes treated with dipeptidyl-peptidase IV inhibitors were more likely to develop pancreatic cancer than those who received other treatment.

Adults with type 2 diabetes who are treated with DPP-IV inhibitors are more likely to develop pancreatitis and pancreatic cancer compared with those treated with other medications, according to findings published in Diabetes Care.

High-value care appeared associated with important patient, tumor and treatment characteristics among patients with early-stage pancreatic cancer who underwent curative resection, according to results of a retrospective study published in JAMA Surgery.

The combination of adavosertib, gemcitabine and radiation appeared safe and potentially effective for patients with newly diagnosed, locally advanced pancreatic cancer, according to results of a phase 1 dose-escalation study published in Journal of Clinical Oncology.

Sita Kugel, PhD, a scientist at Fred Hutchinson Cancer Research Center, received an NCI award that will fund her laboratory’s research into an aggressive form of pancreatic cancer.

The U.S. Preventive Services Task Force reaffirmed its stance against pancreatic cancer screening for asymptomatic adults with no family history of the disease.