Osteoarthritis

TPX-100, a novel 23-amino acid peptide, has a “significant effect” on bone shape, as measured by B-score, in knee osteoarthritis and shows promise as a disease-modifying drug, according to data published in Arthritis Research & Therapy.

Race was not a “substantial, independent predictor” of functional outcomes following total knee replacement, but marginal differences in care were observed across treatment settings, according to data published in Arthritis Care & Research.

A reminder of some common and not-so-common clinical scenarios can make every rheumatologist more capable of delivering optimal patient care, according to a presenter at the 2021 Congress of Clinical Rheumatology-West.

Among patients with arthritis, receiving exercise recommendations from a physician is “critical” to meeting physical activity guidelines and relieving symptom burden, regardless of race and ethnicity, researchers noted in BMC Public Health.

A daily 300 mg dose of tramadol — but not 100 or 200 mg doses — surpassed placebo in improving pain and function related to hip or knee osteoarthritis, but was linked to increasing adverse events, researchers noted in Arthritis Care & Research.

Semi-automated quantitative joint space width at the 50-degree location is sensitive to change as a measure of hip joint space over time, and is associated with hip osteoarthritis in women, according to data.

Just 23% of Medicare beneficiaries with osteoarthritis who eventually underwent knee replacement ever had a physical therapy visit, according to data published in Arthritis & Rheumatology.

Patients with chronic non-inflammatory musculoskeletal disease often experience sexual dysfunction and negative effects on their relationships because of their condition, according to a meta-analysis published in Arthritis Care & Research.

Patients with knee osteoarthritis who use opioids showed worse baseline structural degeneration and faster progression and had greater quality of life loss compared with controls, according to data published in Arthritis Research & Therapy.

Improvements in articular cartilage thickness among patients with knee osteoarthritis who received sprifermin, versus placebo, during the FORWARD trial were maintained over a 3.5- to 4-year follow-up period, according to data.