Obesity

SAN DIEGO — Adults with obesity and type 2 diabetes achieved a 14.7% weight loss at 72 weeks with 15 mg tirzepatide, according to data from the SURMOUNT-2 trial presented at the American Diabetes Association Scientific Sessions.

SAN DIEGO — Adults with obesity and without diabetes receiving the oral GLP-1 receptor agonist orforglipron lost 8.6% to 12.6% of their body weight at 26 weeks, according to a data from a phase 2 trial.

Obesity can have a significant impact on mental health.

Obesity appeared strongly associated with clonal hematopoiesis of indeterminate potential — a blood condition linked to increased risk for blood cancer, according to study results published in The Journal of Clinical Investigation.

Results published in the Journal of Arthroplasty showed patients with class II and class III obesity do not benefit or harm from preoperative weight loss prior to total knee arthroplasty.

Increased adalimumab dosage may improve disease severity in patients with overweight or obesity with moderate to severe hidradenitis suppurativa, according to a study.

Patients who underwent bariatric surgery for morbid obesity had a “substantial and long-lasting reduction” of lipid-lowering and antidiabetic medication use compared with patients who did not undergo surgery.

CHICAGO — A small cohort of adults with obesity and prediabetes had lower glucose elevations and spent less time above range when they ate most of their calories before 1 p.m. compared with a more typical, later eating pattern.

CHICAGO — BMI can underestimate obesity compared with body fat percentage determined by DXA scans, particularly among some racial and ethnic groups, according to data presented at ENDO 2023.

Mitchell A. Lazar, MD, PhD, has always been interested in organic chemistry, biochemistry and mental illness, which led him to delve into research on the regulation of gene expression in response to hormones, metabolites and drugs.