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Nonalcoholic Fatty Liver Disease

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October 14, 2019
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Egrifta reduces hepatic fat fraction in patients with NAFLD, HIV

Treatment with Egrifta demonstrated a greater reduction in hepatic fat fraction compared with placebo among patients with nonalcoholic fatty liver disease and HIV, according to study results.

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October 11, 2019
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Liver fat changes unreliable for some histological predictions

Changes in liver fat can predict changes in steatosis but not other liver histological parameters like improvements in nonalcoholic fatty liver disease activity score or resolution of nonalcoholic steatohepatitis without worsening of fibrosis, according to data published in Journal of Hepatology.

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October 11, 2019
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Psoriasis severity affects severity of nonalcoholic fatty liver disease

Prospective study data presented at the European Academy of Dermatology and Venereology Congress demonstrated that psoriasis severity is associated with more severe hepatic damage among patients with both psoriasis and nonalcoholic fatty liver disease. Specifically, an increase in PASI score by one was associated with an increase in elastography of, on average, 0.26 kPa.

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October 09, 2019
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Consuming dietary fiber may reduce NAFLD risk among multiple ethnicities

Researchers found that while consumption of red and processed meat, poultry, and cholesterol correlated with nonalcoholic fatty liver disease, dietary fiber intake may reduce the risk for fatty liver and related advanced liver disease, according to data from a multiethnic cohort study.

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October 09, 2019
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Axcella completes enrollment in metabolic modulator trial for NAFLD

Investigators have completed trial enrollment for two novel compositions of endogenous metabolic modulators under evaluation as interventions to address dysregulated metabolism in patients with nonalcoholic fatty liver disease, according to a press release from Axcella.

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October 07, 2019
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NGM Bio FGF19 therapy reduces liver fat in patients with NASH-fibrosis

NGM Bio FGF19 therapy reduces liver fat in patients with NASH-fibrosis

NGM Bio announced positive interim results from ongoing study of aldafermin, an engineered version of human fibroblast growth factor 19 that demonstrated reductions in liver fat among patients with nonalcoholic steatohepatitis, according to a press release.

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October 04, 2019
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Saroglitazar magnesium lowers ALT, hepatic fat in NAFLD

Results from the EVIDENCES IV trial showed that saroglitazar magnesium achieved its primary endpoint of reduced alanine aminotransferase in patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, according to a press release from Zydus Calida.

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October 04, 2019
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Healio announces its Disruptive Innovators finalists

Healio announces its Disruptive Innovators finalists

SAN ANTONIO — Healio will host its second Disruptive Innovators reception during the American College of Gastroenterology’s Annual Scientific Meeting (ACG 2019) on October 27, 2019, at the Grand Hyatt San Antonio.

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October 03, 2019
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Quantification of key parameters accurately stages fibrosis in NAFLD

Dual-photon microscopy automated quantification of fibrosis-related parameters provided accurate assessments of fibrosis in patients with nonalcoholic fatty liver disease, according to data published in Gut.

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September 30, 2019
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FXR candidate for NASH reduces alanine transaminase, liver fat

Enanta Pharmaceuticals announced positive results in alanine aminotransferase and liver fat content reduction from its current trial of EDP-305, a small molecule farnesoid X receptor under investigation for the treatment of nonalcoholic steatohepatitis, according to a press release.

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