Neurologic Manifestations

More than 90% of patients in a prospective, observational study of approximately 600 experienced issues related to functional outcomes, activities of daily living, mental health and sleep 6 months after hospitalization for COVID-19.

Many children and adolescents with COVID-19 or multisystem inflammatory syndrome experienced neurologic involvement, with largely transient symptoms, according to a case series of almost 1,700 patients published in JAMA Neurology.

SARS-CoV-2 spike proteins triggered a proinflammatory response in brain endothelial cells that may influence a change in the function of the blood-brain barrier, according to findings published in Neurobiology of Disease.

Neurologic manifestations occurred often in a large cohort of patients with COVID-19, regardless of respiratory disease severity, according to a retrospective analysis conducted in the Chicago area during the early months of the pandemic.

A review in JAMA Neurology concluded that clinicians should monitor patients with COVID-19 for neurological disorders, but more research is needed to further examine the role of SARS-CoV-2 as a contributor to postinfectious neurologic complications, one of the review’s authors told Healio Primary Care.