Myocardial Fibrosis

WASHINGTON — Among patients with asymptomatic severe aortic stenosis and myocardial fibrosis, transcatheter or surgical aortic valve replacement did not improve outcomes compared with guideline-directed conservative management.

Increased exposure to air pollution may lead to higher risk for myocardial fibrosis in patients with chronic kidney disease, according to a speaker at ASN Kidney Week.

In a new study, young adults born preterm demonstrated increased extracellular volume fraction in the left ventricle compared with their term-born peers, which may underlie their diastolic functional impairments.

Compared with those without HIV, HIV-positive individuals had higher rates of sudden cardiac death and myocardial fibrosis, and one-third of sudden cardiac deaths in people with HIV were due to occult drug overdose, researchers reported.

In patients with HF with preserved ejection fraction, pirfenidone was associated with reduction in myocardial fibrosis compared with placebo, according to a presentation at the American College of Cardiology Scientific Session.

For patients living with HIV on long-term highly active antiretroviral therapy, diffuse myocardial fibrosis and left ventricular remodeling may be predictive of adverse CV events, according to data published in JACC: Cardiovascular Imaging.

Galectin-3 interacted with risk for fatal CV events associated with aldosterone in patients referred for coronary angiography, according to a study published in The American Journal of Cardiology.

In patients with nonobstructive hypertrophic cardiomyopathy, treatment with mavacamten was well tolerated and reduced biomarkers of cardiac injury and wall stress, according to results of the phase 2 MAVERICK-HCM study.