Mutation

Certain genetic mutations in breast cancer predisposition genes could inform screening and improve management of women at low risk for the disease, according to results of two studies published in The New England Journal of Medicine.

CDC researchers reported recently that a more highly transmissible SARS-CoV-2 variant first detected in the United Kingdom could soon become the dominant variant in the United States, potentially complicating the U.S. response.

Patients acquired myeloproliferative neoplasm driver mutations early in life, often in utero, which then expanded at variable rates over their lifetime before diagnosis, according to study results.

Researchers successfully created a CAR T-cell construct to signal CD58 mutation or loss in patients with large B cell lymphomas, according to a presentation from the ASH Annual Meeting and Exposition.

Patients with chronic lymphocytic leukemia who carried the IGLV3-21R110 mutation appeared to have poor outcomes, according to study results presented at the virtual ASH Annual Meeting and Exposition.

The 2017 European LeukemiaNet recommendations should be refined to include certain gene mutations that could help determine which patients with acute myeloid leukemia require more intensive treatment, according to study results.

Larotrectinib appeared highly effective for adults and children with tropomyosin receptor kinase fusion cancers, according to study results presented at the virtual American Association for Cancer Research Annual Meeting.

Tipifarnib induced durable objective responses among patients with metastatic or recurrent head and neck squamous cell carcinoma with HRAS mutations, according to results of a single-arm phase 2 study presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.