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Motor Function

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April 10, 2025
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TEMPO trials: Fixed, flexible doses of tavapadon improve motor function in Parkinson’s

SAN DIEGO — Fixed and flexible doses of tavapadon significantly improved motor function compared with placebo in patients with Parkinson’s disease, according to a pair of phase 3 trials presented at the American Academy of Neurology annual meeting.

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April 01, 2025
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Gene therapy improves motor function in spinal muscular atrophy at 52 weeks

Intrathecal treatment with a vector-based gene therapy was associated with a greater improvement in motor function at 52 weeks compared with sham in patients aged 2 to 18 years with spinal muscular atrophy, data show.

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January 21, 2025
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Tofersen improves functional independence in SOD-1 ALS

Treatment with tofersen in patients with superoxide 1 dismutase 1 ALS was linked to preservation of motor function, maintenance of muscle strength and reduction of disease-specific biomarkers, data show.

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October 10, 2024
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Apitegromab improves motor function in spinal muscular atrophy as early as week 8

Topline results from the phase 3 SAPPHIRE clinical trial showed that an investigational muscle-targeted therapy improved motor function in patients with spinal muscular atrophy compared with placebo as early as week 8.

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September 06, 2024
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Higher dose of Spinraza improves motor function in infants with spinal muscular atrophy

Topline data from an ongoing clinical trial of a higher dose regimen of Spinraza in treatment-naive, symptomatic infants with spinal muscular atrophy showed significantly improved motor function at 6 months.

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August 12, 2024
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Spinal muscular atrophy therapy leads to sustained motor function improvement

An investigational, fully human monoclonal antibody developed as a muscle-targeted therapy for spinal muscular atrophy showed sustained motor function improvements at 48 months, according to the manufacturer.

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July 10, 2024
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Interim phase 1/2a study results positive for investigational Parkinson’s cell therapy

A South Korean biomedical company has announced positive 1-year assessment data from a phase 1/2a clinical trial of a human embryonic stem cell-derived midbrain dopaminergic progenitor for Parkinson’s disease.

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June 12, 2024
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Evrysdi linked to significantly improved outcomes in spinal muscular atrophy at 5 years

Newly released data from the open-label extension of the FIREFISH study confirmed sustained safety and efficacy of Evrysdi in children with type 1 spinal muscular atrophy over 5 years.

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March 12, 2024
2 min read
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Nusinersen linked to improved motor function in spinal muscular atrophy

Treatment with nusinersen was linked to increased motor function and reduction of the neurodegenerative biomarker neurofilament light chain in children with spinal muscular atrophy, according to interim results of a study.

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March 08, 2024
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Apitegromab linked to improved outcomes for those with spinal muscular atrophy

Treatment with apitegromab was linked to improved muscle strength and range of motion, while being safe and well-tolerated in those with spinal muscular atrophy types 2 and 3, according to a poster presentation.

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