Monoclonal Antibody

One subcutaneous dose of an experimental monoclonal antibody protected children from infection and clinical malaria during a 6-month malaria season in Mali, according to phase 2 results published in The New England Journal of Medicine.

Patients with active psoriatic arthritis who receive guselkumab demonstrate reduced work impairment, improved overall health and “substantial cost savings” through 2 years, according to data published in Rheumatology and Therapy.

The monoclonal antibody nirsevimab is 90% effective at preventing respiratory syncytial virus hospitalization in infants, according to research published in MMWR.

Sikander Ailawadhi, MD, discusses positioning different therapies and navigate the treatment landscape in multiple myeloma.

A biotechnology company announced the first patient was dosed in its phase 2a clinical trial of intranasal foralumab, a monoclonal antibody treatment for those with non-active secondary-progressive multiple sclerosis.

The FDA has granted fast track designation to Chemomab Therapeutics’ anti-CCL24 monoclonal antibody, CM-101, for the treatment of adults with primary sclerosing cholangitis, according to a manufacturer release.

A clinical-stage biotechnology company has been awarded a multiyear grant totaling $14.8 million from the National Institute on Drug Abuse to develop a subcutaneous formulation of an anti-fentanyl monoclonal antibody.

Ajovy significantly reduced depression symptoms and monthly migraine days in a phase 4 study, with clinically meaningful improvements in disability outcomes, manufacturer Teva Pharmaceuticals announced in a press release.

The FDA has issued a complete response letter for Eli Lilly and Company’s lebrikizumab biologics license application for moderate to severe atopic dermatitis treatment, according to a manufacturer-issued press release.

Nearly half a million Americans are diagnosed with Clostridioides difficile infection each year. Although often treated with antibiotics, C. difficile recurrence is possible. However, recently developed therapies may change this paradigm.