Mitochondrial Dysfunction

The current state of treatment for geographic atrophy is marked by two approved therapies that slow GA progression: pegcetacoplan, or Syfovre, from Apellis Pharmaceuticals and avacincaptad pegol, or Izervay, from Astellas.

Last year, a presentation at the American College of Rheumatology Convergence provided a glimpse into a potential mechanism of inflammation in rheumatoid arthritis that may fundamentally alter treatment approaches.

DENVER — A combination therapeutic for amyotrophic lateral sclerosis was nonsuperior to placebo over 48 weeks in a phase 3 clinical trial, according to a presenter at the American Academy of Neurology annual meeting.

The European Medicines Agency has approved enrollment for a phase 1/2a biomarker study to examine a once-daily, oral, brain penetrant mitochondrial stimulator to treat a range of neurological and neuromuscular conditions.

Following SARS-CoV-2 infection, mitochondrial function remained impaired in the heart, liver and kidneys, despite observed recovery in the lungs, according to a human autopsy and animal tissue study.

Mitochondrial flavoprotein fluorescence may possibly serve as an indicator of age-related macular degeneration stage, helping to detect early disease and offering insights on how and when to treat patients, according to a study.

Researchers at Invicro have found evidence supporting cellular stress and bioenergetic abnormalities in patients with early-stage Alzheimer's disease, according to new data published in Science Translational Medicine.

Xanthine oxidase and mitochondrial DNA damage-associated molecular patterns may represent novel biomarkers of resistant hypertension among Black patients, researchers reported.

Daily consumption of cocoa with epicatechin improved 6-minute walk distance, blood flow to the legs and skeletal muscle health in patients with peripheral artery disease, according to a study published in Circulation Research.

Primary open-angle glaucoma was found to be associated with lower plasmatic nicotinamide levels, and researchers suggest that the vitamin may have future therapeutic use.