Methotrexate

An increased proportion of patients with uncontrolled gout maintained treatment response at 6 months with concomitant methotrexate and pegloticase, compared with pegloticase alone, according to data published in The Journal of Rheumatology.

Subcutaneous methotrexate is safe in clinical practice, and is continued longer and better tolerated than other therapy groups, particularly oral methotrexate, according to data published in Arthritis Care & Research.

Patients with inflammatory bowel disease discontinued methotrexate therapy at twice the rate seen in those who used optimized thiopurine therapy, according to study results.

Ixekizumab demonstrated significantly greater joint and skin improvement, through week 52, than adalimumab among patients with psoriatic arthritis, according to data published in the Annals of the Rheumatic Diseases.

Although there is a wide array of therapies for patients with rheumatoid arthritis, the choice of when and how aggressively to employ them can sometimes conflict with established guidelines, according to a presenter.

Methotrexate is an old friend of dermatologists that we know well.

Upadacitinib monotherapy, at 15 or 30 mg daily, significantly improves clinical, radiographic and patient-reported outcomes in rheumatoid arthritis, compared with weekly methotrexate, according to data published in Arthritis & Rheumatology.

Methotrexate use by patients with rheumatoid arthritis was not associated with an increased risk for developing interstitial lung disease, according to a study published in European Respiratory Journal.

Etanercept monotherapy or a combination of etanercept and methotrexate had better psoriasis outcomes than methotrexate alone, according to a poster presented at the American Academy of Dermatology virtual meeting.

Combination therapy with TNF inhibitors plus methotrexate was significantly superior to triple therapy with methotrexate, hydroxychloroquine and sulfasalazine in patients with rheumatoid arthritis, both in terms of persistence and improved disease activity, according to data published in Arthritis Care & Research.