Metformin

BALTIMORE — Most children with youth-onset type 2 diabetes develop macrovascular or microvascular complications within a decade of diagnosis, and the risk for beta cell function failure increases over time, according to a speaker.

NEW YORK — Patients taking lower doses of metformin may be at lower risk for age-related macular degeneration, revealing a potential novel therapy strategy, according to a speaker at the American Society of Retina Specialists meeting.

ATLANTA — Adults with type 2 diabetes who were prescribed insulin had greater risks for major osteoporotic and hip fractures than those prescribed metformin, according to study data.

In a recent study, researchers found no between-group differences in myocardial infarction, stroke or cardiovascular death among patients with prediabetes who received metformin, a lifestyle intervention or placebo.

For patients with type 2 diabetes, first-line SGLT2 inhibitors might be better than metformin when it comes to their cardiovascular health, according to results of a population-based cohort study.

In adults with prediabetes, metformin and lifestyle interventions decreased the likelihood of type 2 diabetes development but did not reduce risk for major adverse CV events compared with placebo during 21 years of follow-up, data show.

Type 2 diabetes overtreatment among nursing home residents is common, with few residents having their medication regimens appropriately deintensified, according to results published in the Journal of the American Geriatric Society.

Children whose fathers who took metformin before conception are more likely to have major birth defects, especially male genital birth defects, compared with no paternal preconception exposure, according to study findings.

Combination therapy with a GLP-1 receptor agonist and an SGLT2 inhibitor may provide better weight-loss benefits than a single agent for women with polycystic ovary syndrome and obesity, according to study data.

The American Diabetes Association recently issued its 2022 Standards of Care, which includes recommendations for screening and first-line therapy. It was the top story in Endocrinology last week.