Metabolic Syndrome

CHICAGO — Patients with metabolic syndrome are at risk for developing HF with preserved ejection fraction, although the mechanisms behind this risk are speculative at the moment, according to a presentation at the Cardiometabolic Health Congress.

CHICAGO — Intensive lifestyle interventions and metformin therapy have had significant success in treating type 2 diabetes and should both be considered when deciding on prevention and treatment, according to a presentation at the Cardiometabolic Health Congress.

Approximately 1 in 4 Swedish women with severe obesity has polycystic ovary syndrome and more than 40% have metabolic syndrome, although women with and without PCOS had comparable body composition measurements and experienced similar weight loss during a dietary intervention, according to findings published in Clinical Endocrinology.

Metabolic syndrome status does not affect Ilumya efficacy, safety or drug survival in patients with moderate to severe chronic psoriasis, according to post hoc analyses from two phase 3 studies, reSURFACE 1 and 2.

Primary biliary cholangitis is a chronic autoimmune disease that causes progressive destruction of the bile ducts. While the disease is considered rare with fewer than 200,000 cases in the U.S. per year, many physicians and patient advocacy groups have made strides toward increasing awareness about the disease, as early diagnosis and treatment can help to manage complications and prevent progression of inflammation and fibrosis.

Approximately 30% of Americans have fatty liver, but only a small proportion have progressed to nonalcoholic steatohepatitis. One of the complications that we face in finding these patients is that our current treatment guidelines for nonalcoholic fatty liver disease do not recommend routine screening. Additionally, it is not feasible to send every patient with potential risk factors for an invasive procedure like liver biopsy. What we have at our disposal, however, are some very simple noninvasive biomarkers and tools to help stratify which patients should be followed for fatty liver and its progression.

Among the top stories in endocrinology last week were findings that suggested adults who practiced a combination of healthy lifestyle factors more than halved their risk for developing type 2 diabetes and a study that determined children exposed to gestational diabetes in utero who were exclusively breastfed were less likely to develop obesity if intake of sugar-sweetened beverages was also low.

Approximately 30% of Americans have fatty liver disease often driven by obesity and alcohol use. Fatty liver disease leads to many other complications including fasting glucose impairment or diabetes, cardiovascular disease, certain cancers, and can exacerbate the effects of other liver diseases such as hepatitis C.

Metabolic syndrome severity may influence the risk for coronary heart disease and diabetes both when it is evaluated in a fasting state and a nonfasting state, according to findings published in Nutrition, Metabolism and Cardiovascular Diseases.

Adults with type 2 diabetes and higher C-peptide levels are more likely to develop simple nonalcoholic fatty liver disease and nonalcoholic steatohepatitis compared with those with lower levels, according to findings published in DiabetesMetabolism Research and Reviews. In contrast, those with higher C-peptide levels are less likely to have advanced fibrosis.