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Mcmaster University

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September 15, 2023
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Gefapixant yields modest improvements in refractory, unexplained chronic cough vs. placebo

Gefapixant yields modest improvements in refractory, unexplained chronic cough vs. placebo

Gefapixant only showed small effects vs. placebo on objective cough frequency, cough severity and quality of life among adults with refractory or unexplained chronic cough, according to results of a systematic review and meta-analysis.

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August 25, 2023
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Colchicine not protective against AF, myocardial injury after noncardiac chest surgery

Colchicine not protective against AF, myocardial injury after noncardiac chest surgery

Colchicine did not reduce risk for perioperative atrial fibrillation or myocardial injury vs. placebo after noncardiac chest surgery, but a speaker noted a slight trend toward protection from a composite of both outcomes.

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July 07, 2023
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Healthy diet including full-fat dairy lowers risk for heart disease, death worldwide

Healthy diet including full-fat dairy lowers risk for heart disease, death worldwide

Researchers reported that a diet comprised of higher amounts of fruit, vegetables, nuts, legumes, fish and whole-fat dairy is associated with lower CVD and mortality in all world regions, especially in countries with lower income.

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June 28, 2023
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Concizumab prophylaxis significantly reduces bleeding events for people with hemophilia

Concizumab prophylaxis significantly reduces bleeding events for people with hemophilia

Prophylactic concizumab conferred significant reductions in treated spontaneous and traumatic bleeds among patients with hemophilia A or B without inhibitors, a primary analysis of the randomized phase 3 explorer8 study showed.

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June 23, 2023
7 min read
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A ‘mismatch of information’: Exercising with osteoarthritis a matter of hurt vs. harm

A ‘mismatch of information’: Exercising with osteoarthritis a matter of hurt vs. harm

As a seemingly ever-increasing body of data support physical activity in patients with osteoarthritis, a growing discussion is addressing the distinction between pain and harm, and how the two are experienced by those with the disease.

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June 06, 2023
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Andexanet alfa postmarketing trial stopped early due to superior efficacy

Andexanet alfa postmarketing trial stopped early due to superior efficacy

AstraZeneca announced the ANNEXA phase IV trial assessing the safety and efficacy of andexanet alfa stopped early after achieving prespecified criteria on hemostatic efficacy vs. usual care, according to a press release.

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May 23, 2023
3 min read
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Leads from transvenous ICDs confer tricuspid regurgitation

Leads from transvenous ICDs confer tricuspid regurgitation

In patients with an implantable cardioverter defibrillator, those who had transvenous leads had worse outcomes related to tricuspid regurgitation than those who had subcutaneous leads, according to new data from the ATLAS trial.

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May 16, 2023
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Heart failure hospitalization, mortality varies globally by national economic level

Heart failure hospitalization, mortality varies globally by national economic level

After adjusting for factors including use of long-term therapies, the risk for mortality within 30 days of first heart failure hospitalization was between three- and fivefold higher in lower-income vs. higher-income countries, data show.

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April 19, 2023
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Early treatment with fluvoxamine, inhaled budesonide reduces severe COVID-19 risk

Early treatment with fluvoxamine, inhaled budesonide reduces severe COVID-19 risk

Early treatment with oral fluvoxamine plus inhaled budesonide reduced the incidence of progression to severe disease among high-risk outpatients with COVID-19, according to research published in Annals of Internal Medicine.

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March 20, 2023
3 min read
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Diabetic retinopathy prevalence increases over time in pediatric type 2 diabetes

Diabetic retinopathy prevalence increases over time in pediatric type 2 diabetes

The prevalence of diabetic retinopathy among children and adolescents with type 2 diabetes greatly increases 5 years after diabetes diagnosis, according to findings from a systematic review and meta-analysis.

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