Massachusetts General Hospital

Asciminib appeared to be more effective than bosutinib for certain patients with chronic-phase chronic myeloid leukemia who had been treated with at least two tyrosine kinase inhibitors, according to results of the phase 3 ASCEMBL study.

Abnormal ECG findings were more common in female athletes compared with male athletes, according to a study published in JAMA Cardiology.

Avoiding obesity, alcohol consumption and diuretic use, while maintaining a DASH-style diet, may prevent most incident gout cases among men, according to data published in JAMA Network Open.

Lorlatinib appeared to be an effective first-line therapy compared with crizotinib among patients with advanced ALK-positive non-small cell lung cancer, according to phase 3 study results published in The New England Journal of Medicine.

Despite no notable differences in hip function or pain in patients who underwent total hip arthroplasty, vitamin E-diffused polyethylene liners had “significantly less liner wear” than crosslinked polyethylene liners at 7-year follow-up.

An LPA genetic risk score with 43 single nucleotide variants provided similar risk prediction for atherosclerotic CVD compared with measuring lipoprotein(a), researchers found.

Allogeneic or “off-the-shelf” chimeric antigen receptor T-cell therapies have moved into early-phase clinical testing with the hope that they will offer many advantages over autologous regimens.

All adults should begin to get screened for colorectal cancer at age 45 years, according to a draft recommendation by the U.S. Preventive Services Task Force.

Recently, there has been renewed interest in the treatment of higher-risk patients undergoing PCI for complex CAD. Novel techniques and equipment have expanded operators’ ability to treat patients with increasingly complicated lesion types.

IgG4-related disease treatment is expected evolve greatly over the next 3 to 5 years, with a trio of promising drugs — inebilizumab, rilzabrutinib and elotuzumab — on the horizon, according to a speaker at the 2020 Congress of Clinical Rheumatology-West.