Massachusetts General Hospital
Growth hormone reduces liver fat, inflammation in adults with NAFLD
ATLANTA — Adults with overweight or obesity and nonalcoholic fatty liver disease, or NAFLD, had a significant reduction in liver fat and inflammation with daily subcutaneous growth hormone administration, according to a speaker.
Uncertainty leads to depression, anxiety in patients with systemic autoimmune diseases
Patients with systemic autoimmune rheumatic disorders who show evidence of illness-related uncertainty also tend to experience depression, anxiety and increased sickness impact, according to data published in the Journal of Rheumatology.
Lower tibial cortical BMD, bone strength observed in male runners vs. nonathletes
ATLANTA — Male runners are more likely to have lower tibial bone mineral density and strength compared with nonathletes, according to a presenter at ENDO 2022.
Sequential pembrolizumab may be optimal timing with chemoradiotherapy in head/neck cancer
CHICAGO — A sequential schedule of fixed-dose pembrolizumab with chemoradiotherapy conferred numerically higher PFS rates vs. concurrent timing of the drug among patients with locally advanced head and neck cancer, study results showed.
Adjuvant chemotherapy plus endocrine therapy fails to increase OS in breast cancer subset
CHICAGO — The addition of chemotherapy to endocrine therapy did not extend OS after surgery among older patients with ER-positive, HER2-negative breast cancer with a high tumor genomic grade index.
Acetaminophen may reduce immunotherapy efficacy in patients with cancer
CHICAGO — Acetaminophen suppressed antitumor immunity in a cohort of patients with cancer, according to study results presented during ASCO Annual Meeting.
First patient gains insulin independence with novel stem cell-derived islet cell therapy
NEW ORLEANS — A man with long-standing type 1 diabetes and no endogenous insulin production achieved insulin independence after an infusion of an investigational stem cell-derived pancreatic islet cell therapy, researchers reported.
Investigational CAR-T shows promise for advanced multiple myeloma
CHICAGO — A single dose of a novel chimeric antigen receptor T-cell therapy induced objective response among all treated patients with relapsed or refractory multiple myeloma, according to study results presented at ASCO Annual Meeting.
Polygenic component associated with HCM risk, offering prediction tool
Rare and common genetic variants contribute substantially to susceptibility to hypertrophic cardiomyopathy in the general population and can help improve risk prediction beyond clinical factors, researchers reported.
Genetic risk, low diet quality increase type 2 diabetes risk
Genetic risk and poorer diet quality each independently increase the risk for developing type 2 diabetes, according to study data.