Massachusetts General Hospital
GRADE: Insulin glargine, liraglutide better maintain glycemic control than other agents
Insulin glargine and the GLP-1 receptor agonist liraglutide are more effective at achieving an HbA1c of less than 7% than the sulfonylurea glimepiride or the DPP-IV inhibitor sitagliptin, according to data from the GRADE trial.
Cancer-related fatigue may impact balance after breast cancer treatment
Cancer-related fatigue appeared associated with greater postural sway among a cohort of breast cancer survivors, according to study results published in Rehabilitation Oncology.
Adagrasib alone, with cetuximab shows ‘encouraging’ activity in advanced colorectal cancer
Adagrasib alone and in combination with cetuximab exhibited promising efficacy compared with historical outcomes among heavily pretreated patients with advanced colorectal cancer who had KRASG12C mutations.
Immune environment may dictate durability of response to CAR-T for multiple myeloma
Prolonged responses to chimeric antigen receptor T-cell therapy for advanced multiple myeloma may depend on the composition of the patient’s post-treatment immune microenvironment, results from a retrospective study showed.
Liquid biopsy may improve detection of brain tumor mutations
Researchers at Massachusetts General Hospital have developed a new blood test to detect epidermal growth factor receptor mutations in patients with glioma — one of the most common brain cancers in adults.
Routine cardiology care ‘suffered greatly’ for many during pandemic
The COVID-19 pandemic has had a profound effect on cardiology care, changing how, when and where physicians interact with their patients in ways large and small, seemingly overnight.
Combined monogenic, polygenic risk prediction spurs changes in CAD management
A combined monogenic and polygenic risk assessment for CAD can identify individuals at high inherited risk before overt manifestation of traditional risk factors, potentially improving clinician decision-making on preventive interventions.
Study: 1.4% of patients with cervical trauma needed referral to ED after urgent care visit
Patient-initiated urgent care center visits for low acuity, cervical spine trauma were linked with reduced ED referrals, as well as imaging and health care costs, according to published results.
Delayed vs. early surgery linked to shorter survival in advanced esophageal cancer
Early surgery prolonged survival compared with delayed surgery among patients with stage II to stage III esophageal cancer, according to study results published in Journal of the American College of Surgeons.
Gout more prevalent among Black adults, men
In the United States, gout is more prevalent among Black adults than white adults, as well as among men compared with women, according to data published in JAMA Network Open.